Diabetic Foot Clinical Trial
Official title:
Clinical Evaluation and Generalized Application of "Qing-Hua-Bu" Three Dynamic Sequential Therapy of Diabetic Ulcer
This project is based on investigator team's ten year experience on diabetic ulcer and goes on further developing basic research and concluding clinical experience. The investigator team has recently developed "Remove stasis to generate granulation tissue" into "Remove slough to generate granulation tissue". Investigators have applied the principle of "Remove stasis" in the medium and later stage of treatment to make "Remove slough-Eliminate stasis-Generate granulation tissue" become the basic principle of three-stage sequential treatment. Investigators will further conclude Chinese medicine therapy in the stage of "Qing-Hua-Bu" and evaluate safety, applicability and availability of it. Therefore, the research can help improve clinical diagnosis and treatment technique and transfer the study result of Chinese medicine experience on diabetic ulcer.
Aim: Under guidance of "Clear pus-Remove stasis-Supplement muscles" theory, to observe
clinical effectiveness of dynamic Chinese external therapy of "Qing-Hua-Bu" in treating
diabetic ulcer and partially explain potential wound healing mechanism.
Method: Clinical observation: To adopt the design method of open and parallel control test
and include 150 diabetic ulcer patients. The treatment group was supplied with external
clearing heat, removing stasis and supplementing deficiency Chinese medicine, while the
control group was supplied with sulfadiazine silver cream, furacilin solution and bovine
basic fibroblast growth factors (b-FGF) spray. To perform the dressing change for wound every
day and persist in dressing change for two months. To record dynamic wound healing progress
by digital camera. After finishing course, to compare wound healing, pus, exudate,
granulation tissues and epithelial tissues and analyze these data by SPSS22.0.
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