Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever

Status Completed

Clinical Trial Summary

The investigators aim to compare two antibiotic treatments for enteric (typhoid) fever. Three hundred patients at Patan Hospital will be enrolled in the study. Patients will be assigned to one of the two treatments by chance and followed for 6 months. The two treatment groups will be compared to see which treatment is more likely to make the patient better.

Clinical Trial Description

With the study hypothesis that Gatifloxacin is superior to Ceftriaxone in terms of treatment failure in patients with enteric fever, a comparative study will be conducted at Patan Hospital. 300 patients who are diagnosed with enteric fever will be enrolled into the study. The patients will be randomized to one of two groups. One group will receive treatment with Gatifloxacin for 7 days, and the other with Ceftriaxone. The patients will be followed during the treatment courses and at several points of 6 months after initial presentation. The endpoints then will be compared between two groups. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01421693
Study type	Interventional
Source	Oxford University Clinical Research Unit, Vietnam
Contact
Status	Completed
Phase	Phase 4
Start date	September 2011
Completion date	January 2015

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04830371` - Non-inferiority and Safety Study of EuTCV Compared to Typbar-TCV in Healthy 6 Months-45 Years Aged Participants	Phase 2/Phase 3
Recruiting	`NCT04543877` - WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study	Early Phase 1
Completed	`NCT02324751` - Vaccines Against Salmonella Typhi	Phase 2
Completed	`NCT05579821` - Evaluation Study of DPP® Typhoid Assay
Completed	`NCT02947295` - Global Genomic and Proteomic Profiling of African Children With Typhoid Fever
Completed	`NCT01405521` - Understanding Typhoid Disease After Vaccination	Phase 2
Completed	`NCT00386789` - Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age	N/A
Completed	`NCT04801602` - Commercial Typhoid Tests Validation Trial
Recruiting	`NCT06104345` - Immune Response Elicited by Concomitant Administration of Oral Typhoid Fever (Vivotif®) and Cholera (Dukoral®) Vaccines	Phase 4
Completed	`NCT01438996` - Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults	Phase 2
Completed	`NCT01437267` - Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants	Phase 2
Completed	`NCT01193907` - Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old)	Phase 2
Recruiting	`NCT04349826` - The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial)	Phase 4
Completed	`NCT01608815` - Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects	Phase 3
Completed	`NCT01123941` - Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old)	Phase 1
Recruiting	`NCT05500482` - Vellore Typhoid Vaccine Impact Trial	Phase 4
Completed	`NCT03926455` - Safety and Immunogenicity of Typhax, a Typhoid Vaccine	Phase 1
Completed	`NCT01229176` - Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants	Phase 2
Completed	`NCT03956524` - Safety and Tolerability of Typhoid Conjugate Vaccine (EuTCV) in Healthy Adults	Phase 1
Completed	`NCT04154722` - Comparison of Two Drugs Regimen in Treatment of Complicated Typhoid Fever in Children	Phase 4