Clinical Trials Logo
  1. Home
  2. Typhoid Fever
  3. NCT01123941

Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adult (18-40 Years Old)

Typhoid Fever Clinical Trial

Official title:
A Phase I, Randomized, Single-Blind, Controlled, Single Center Study to Evaluate the Safety and Immunogenicity of the NVGH Glycoconjugate Vaccine Against S. Typhi in Adult Subjects 18 to 40 Years of Age.

Clinical Trial Summary

This trial is aimed to evaluate the safety and immunogenicity profiles of a new Vi-CRM197 conjugate vaccine against S. Typhi in healthy human adults in comparison with the currently licensed Vi polysaccharide vaccine.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01123941
Study type Interventional
Source Novartis
Contact
Status Completed
Phase Phase 1
Start date May 2010
Completion date November 2010
View Details
See also
  Status Clinical Trial Phase
Completed NCT04830371 - Non-inferiority and Safety Study of EuTCV Compared to Typbar-TCV in Healthy 6 Months-45 Years Aged Participants Phase 2/Phase 3
Recruiting NCT04543877 - WHNRC (Western Human Nutrition Research Center) Fiber Intervention Study Early Phase 1
Completed NCT02324751 - Vaccines Against Salmonella Typhi Phase 2
Completed NCT01421693 - Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever Phase 4
Completed NCT05579821 - Evaluation Study of DPP® Typhoid Assay
Completed NCT02947295 - Global Genomic and Proteomic Profiling of African Children With Typhoid Fever
Completed NCT01405521 - Understanding Typhoid Disease After Vaccination Phase 2
Completed NCT00386789 - Long Term Protection by and Persistence of Vi Antibodies Induced by Vi-rEPA Conjugate Vaccines in Vietnamese Children Injected at 2-5 Years or at 5-8 Years of Age N/A
Completed NCT04801602 - Commercial Typhoid Tests Validation Trial
Recruiting NCT06104345 - Immune Response Elicited by Concomitant Administration of Oral Typhoid Fever (Vivotif®) and Cholera (Dukoral®) Vaccines Phase 4
Completed NCT01437267 - Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Children, Older Infants and Infants Phase 2
Completed NCT01438996 - Extension Study of H01_04TP to Evaluate the Booster Response Induced by Vi-CRM197 in Adults Phase 2
Completed NCT01193907 - Safety and Immunogenicity of Three Formulations of Vi-CRM197 Vaccine Against S. Typhi in Adults (18-40 Years Old) Phase 2
Recruiting NCT04349826 - The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial) Phase 4
Completed NCT01608815 - Study of a Single Dose of SP093 Typhoid Vi Polysaccharide Vaccine in Japanese Subjects Phase 3
Recruiting NCT05500482 - Vellore Typhoid Vaccine Impact Trial Phase 4
Completed NCT03926455 - Safety and Immunogenicity of Typhax, a Typhoid Vaccine Phase 1
Completed NCT01229176 - Safety and Immunogenicity of Vi-CRM197 Vaccine Against S. Typhi in Adults, Children, Older Infants and Infants Phase 2
Completed NCT03956524 - Safety and Tolerability of Typhoid Conjugate Vaccine (EuTCV) in Healthy Adults Phase 1
Completed NCT04154722 - Comparison of Two Drugs Regimen in Treatment of Complicated Typhoid Fever in Children Phase 4