Type 1 Diabetes Clinical Trial
Official title:
Evaluation of a Novel Method for Integrating Insulin Delivery and Glucose Sensing in Subcutaneous Tissue for the Treatment of Type-1 Diabetic Patients
The study seeks to use microdialysis and microperfusion techniques to assess the feasibility of combining insulin delivery and glucose sensing at a single subcutaneous tissue site.
Current treatment of in type 1 diabetes comprises the measurement of glucose in capillary
blood obtained by fingersticking and administration of exogenous insulin in the form of a
subcutaneous bolus injection or subcutaneous infusion. This treatment could be simplified if
there were a stable ratio between blood glucose concentration and tissue glucose level at
the site of insulin delivery so that tissue glucose levels could be used to estimate blood
glucose levels, thereby circumventing the need for fingerstick blood glucose monitoring.
The aim of this study is to ascertain whether a stable ratio between the blood glucose
concentration and the glucose levels at the tissue site of insulin infusion exists when this
tissue site is exposed to variable insulin infusion rates. To achieve this, microdialysis
and microperfusion probes are applied in healthy and type 1 diabetic subjects to perform
insulin delivery and glucose sampling at the same adipose tissue site during euglycemic
clamps and oral glucose tolerance tests.
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Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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