Hypoglycemia Associated Autonomic Failure in Type 1 DM, Q2

Status Completed

Clinical Trial Summary

Alprazolam (Xanax) will blunt the body's ability to defend itself from low blood sugar.

Clinical Trial Description

Due to the fundamental importance of glucose as a cerebral fuel, a complex and redundant counterregulatory response to hypoglycemia exists in man. Some studies have shown that prior activation of GABA(A) receptors may result in blunting of counterregulatory responses during next day hypoglycemia.

The Specific Aim is to determine if repeated activation of GABA(A) receptors using Alprazolam will result in blunting of neuroendocrine, ANS and metabolic counterregulatory mechanisms during next day hypoglycemia in T1DM and healthy man. ;

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject)

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00592332
Study type	Interventional
Source	Vanderbilt University
Contact
Status	Completed
Phase	N/A
Start date	June 2005
Completion date	June 2009

View Details

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