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Twin Pregnancy clinical trials

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NCT ID: NCT05727085 Recruiting - Twin Pregnancy Clinical Trials

Cohort of Twin Pregnancy and the Offspring

CTPO
Start date: July 2023
Phase:
Study type: Observational

Twin pregnancy increases the risk of maternal and fetal complications, which include gestational hypertension, premature labor, twin-to-twin transfusion syndrome, intrauterine growth restriction, anemia, amniotic fluid abnormalities. Comprehensively understanding the molecular mechanisms of the disease and identification of markers contribute to development of novel therapeutic approaches. In addition, the twin pregnancy, especially the monochorionic, is an essential model of "experiments of nature". This model can be applied to distinguish the epigenetic differences of twins in utero and after birth in the same genomic context. The aim of the study is to constitute a prospective cohort of twin pregnancies and the offspring.

NCT ID: NCT05104255 Completed - Neonate Clinical Trials

Neonatal Outcomes in Twin Pregnancies

Start date: January 1, 2017
Phase:
Study type: Observational

Multiple pregnancies are associated with increased maternal and fetal risks compared to singleton pregnancies. Additionally, the cesarean section rate is quite high in multiple pregnancies. This study aimed to evaluate maternal and fetal characteristics and factors affecting fetal outcomes in twin pregnancies delivered by cesarean section.

NCT ID: NCT04588597 Not yet recruiting - Twin Pregnancy Clinical Trials

Obstetric and Neonatal Outcomes of Twin Pregnancy

Twin-CTB
Start date: November 1, 2020
Phase:
Study type: Observational

This multicenter study aims at assessing the natural history of twin pregnancy and developing a machine learning-based algorithm to predict clinical outcomes of twin pregnancy during pregnancy and delivery and to determine management strategies that are associated with best maternal and neonatal outcomes. This study will include at least 12 centers from different countries that present at least Europe, South America, Asia, and Africa. Data will be retrospectively collected from January 1st, 2010 to December 31st, 2019.

NCT ID: NCT04353856 Completed - Twin Pregnancy Clinical Trials

Quality of Life During a Twin Pregnancy

QUALIGEM
Start date: July 7, 2020
Phase:
Study type: Observational

Quality of life has recently appeared as a component of health. Pregnancy has an impact on the quality of life of the parturient, whether through physical or psychological changes. It is common to think that quality of life is altered in the context of a twin pregnancy, but this has never been scientifically demonstrated. The hypothesis is to observe a decrease in the quality of life of pregnant women with twins at the end of pregnancy, in particular in case of a pregnancy-related pathology.

NCT ID: NCT04232436 Completed - Twin Pregnancy Clinical Trials

Planned Vaginal Delivery vs Planned Cesarean Delivery in Preterm Twins

Start date: July 1, 2019
Phase:
Study type: Observational

The incidence of twin pregnancies has increased and currently accounts for 1.8% of all deliveries. 47.5% of twins are born prematurely (vs. 6% for singletons) of which 9.9% before 32SA. Caesarean section rates are also higher than for singletons (53.7% vs 19.2%) and 31.8% of caesarean sections are performed before delivery. The optimal mode of delivery for preterm twins remains controversial. The latest recommendations for clinical practice emphasize that it is not appropriate to recommend one mode of delivery rather than another in the case of twin pregnancies at any term. In view of all these elements, we wished to carry out a retrospective study at the Montpellier University Hospital in order to compare the neonatal outcome of preterms twins according to their mode of delivery : planned vaginal delivery versus planned cesarean delivery.

NCT ID: NCT04051567 Recruiting - Preterm Birth Clinical Trials

Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies

Start date: November 1, 2018
Phase: Phase 4
Study type: Interventional

Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth. Low-dose aspirin was recommend by American College of Obstetricians and Gynecologists (ACOG) during pregnancy. In this trial, the investigators suppose that aspirin used in twin-pregnancies could improve adverse pregnancy outcomes.

NCT ID: NCT03863613 Terminated - Preterm Birth Clinical Trials

Pessary Versus Cerclage With or Without Progesterone in Twins

PCP-Twins
Start date: March 23, 2019
Phase: N/A
Study type: Interventional

This study compares the effectiveness of cervical pessary and cervical cerclage with or without vaginal progesterone for prevention of preterm birth in women with a twin pregnancy and a cervix ≤28 mm. Participants will be randomly assigned in a 1:1:1:1 ratio to receive cerclage, pessary, cerclage plus progesterone or pessary plus progesterone.

NCT ID: NCT03540225 Withdrawn - Premature Birth Clinical Trials

Vaginal Progesterone for the Prevention of Preterm Birth in Twins

POPPET
Start date: April 2020
Phase: Phase 3
Study type: Interventional

This trial is a randomised, multi-centre, 2 x 2 factorial designed pilot trial with two factors of 200mg vs. 400mg progesterone self-administered daily from 11-14 weeks' gestation vs. 20-24 weeks' gestation, to compare the median gestational age (in days) at delivery between the comparison groups.

NCT ID: NCT00502190 Completed - Twin Pregnancy Clinical Trials

Evaluation Of Pessaries In Twin Pregnancies With A Short Cervix (25 mm) Between 20-28 WG (EPEGE)

EPEGE
Start date: June 2007
Phase: Phase 3
Study type: Interventional

Randomized, opened multicentric study evaluating the Effectiveness of Pessary in the patients with a Gemellary pregnancy and a collar runs between 20 and 28 weeks of amenorrhoea

NCT ID: NCT00187369 Completed - Twin Pregnancy Clinical Trials

The Twin Birth Study: A Trial Comparing Planned Vaginal Birth to Elective Caesarean Section of Twins

Start date: December 2003
Phase: N/A
Study type: Interventional

For twin pregnancies at 32-38 weeks gestation, where twin A is head down, does a policy of planned caesarean section (CS) lower the likelihood of death or serious illness, during the first 28 days after birth, compared to a plan for vaginal birth (VB)?