Clinical Trials Logo

Tumour Response, clinical trials

View clinical trials related to Tumour Response,.

Filter by:
  • Completed  
  • Page 1

NCT ID: NCT01895946 Completed - Clinical trials for Safety and Tolerability,

Comparison of Two Formulations of AZD5363 and the Effect of Food on Pharmacokinetic Exposure, Safety and Tolerability

OAK
Start date: December 2013
Phase: Phase 1
Study type: Interventional

Comparison of Two Formulations of AZD5363 and the Effect of Food on Pharmacokinetic Exposure, Safety and Tolerability

NCT ID: NCT01692262 Completed - Pharmacokinetics, Clinical Trials

Investigating Safety, Tolerability and Efficacy of AZD5363 in Prostate Cancer.

PYRUS
Start date: November 2012
Phase: Phase 1
Study type: Interventional

To investigate the safety, tolerability and anti-tumour activity of AZD5363, as monotherapy, in patients with metastatic Castrate-Resistant Prostate Cancer. AZD5363 will be investigated in patients who have progressed after chemotherapy (Part A) and in patients who have progressed before receiving chemotherapy (Part B). Recruitment into Part A, Group 1 has been suspended. A new design for this group is currently being evaluated. Part A, group 2 patients (progressed after 1 or more 2nd generational anti-hormonal therapies) will receive AZD5363 480mg bid intermittently (4 days on/3days off). Part B will only start if there is evidence of anti-tumour activity along with AZD5363 having an acceptable safety profile in Part A. Part B will be conducted in pre-chemotherapy patients on a dose and schedule selected from Part A.