Tuberous Sclerosis Clinical Trial
Official title:
Effect of Fasting on the Size of Lymphangioleiomyomas in Patients With Lymphangioleiomyomatosis
Verified date | March 21, 2016 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
This study will examine the effect of fasting on lymphangioleiomyomas abdominal tumors formed
from enlarged lymph nodes containing lymphatic fluid. Previous studies have determined that
these tumors increase in size in the evening, but this result could stem from the fact that
previous study participants were tested after eating lunch. The purpose of the study is to
help researchers understand the factors that produce changes in size of lymphangioleiomyomas,
as well as to improve the ability of medical professionals to diagnose lymphangioleiomyomas
and avoid confusing these tumors with other malignant tumors.
Volunteers must be women who are at least 18 years of age and who have been diagnosed with
lymphangioleiomyomas in the abdominal or pelvic areas. Candidates who have had lung or kidney
transplants or who have type 1 diabetes will be excluded. Candidates will be screened with a
physical examination and medical history.
During the study, participants will be admitted to a National Institutes of Health clinical
center for three days to undergo a number of tests. Tests will include routine blood and
urine tests, and electrocardiogram, research blood testing, and abdominal and pelvic
ultrasounds....
Status | Completed |
Enrollment | 35 |
Est. completion date | March 21, 2016 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 18 Years to 80 Years |
Eligibility |
- INCLUSION CRITERIA: Individuals who are 18 years of age or older with any of the following: 1. Lymphangioleiomyomatosis 2. Abdominal or pelvic lymphangioleiomyomas equal to or greater than one centimeter in diameter in the non-fasting state. EXCLUSION CRITERIA: Individuals with any of the following: 1. Lung transplantation 2. Kidney transplantation 3. Lymphangioleiomyomas smaller than one centimeter in diameter in the non-fasting state. 4. Pregnancy or lactation. 5. Type 1 diabetes. 6. Inability to give informed consent. 7. Currently taking rapamycin. |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Heart, Lung, and Blood Institute (NHLBI) |
United States,
Chu SC, Horiba K, Usuki J, Avila NA, Chen CC, Travis WD, Ferrans VJ, Moss J. Comprehensive evaluation of 35 patients with lymphangioleiomyomatosis. Chest. 1999 Apr;115(4):1041-52. — View Citation
Johnson SR, Tattersfield AE. Clinical experience of lymphangioleiomyomatosis in the UK. Thorax. 2000 Dec;55(12):1052-7. — View Citation
Kitaichi M, Nishimura K, Itoh H, Izumi T. Pulmonary lymphangioleiomyomatosis: a report of 46 patients including a clinicopathologic study of prognostic factors. Am J Respir Crit Care Med. 1995 Feb;151(2 Pt 1):527-33. — View Citation
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