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Tuberculosis, Pulmonary clinical trials

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NCT ID: NCT04694586 Suspended - Clinical trials for Tuberculosis, Pulmonary

Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and Pyrazinamide

HIGHSHORT-RP
Start date: November 30, 2022
Phase: Phase 2
Study type: Interventional

Tuberculosis (TB) treatment is long and complex with the risk of poor treatment adherence and treatment failure. Several attempts to shorten treatment of drug-susceptible TB have been unsuccessful. However, recent data support a shortened regimen for mild and moderate pulmonary TB and simultaneous optimization of rifampicin (RIF) and pyrazinamide (PZA). This phase II clinical study aim to investigate a strategy to shorten TB treatment by exploring safety and drug exposure of a high-dose sterilizing TB regimen.