Treatment of Patients With Trophic Ulcers Using Mesenchymal Stem Cells

Trophic Ulcer Clinical Trial

Official title: Treatment of Patients With Trophic Ulcers Using Autologous Adipose-derived Mesenchymal Stem Cells

Status Completed

Clinical Trial Summary

Treatment of patients with trophic ulcers using injection of autologous adipose-derived mesenchymal stem cells around and inside the wound

Clinical Trial Description

During the implementation of the project, it was planned to develop a method for the treatment of trophic ulcers using injection of autologous adipose-derived mesenchymal stem cells in the wound. The positive outlook for the effectiveness of MSCs is due to the following:

• the ability of MSCs to stimulate tissue regeneration

• positive results of preclinical studies of the method of treatment of trophic ulcers in animals (rats).

In study were included 18 patients (28 trophic ulcers treated). MSCs will be isolated from adipose tissue, cultured and then transplanted back to the wound. From 1 to 10 million MSCs in 4 ml were injected depending on the area of the wound. Follow up patients monitoring will occur at 1，2 and 3, 6, 12, 22 months after injection. ;

Related Conditions & MeSH terms

• Trophic Ulcer
• Ulcer

• NCT number: NCT04457037
• Study type: Interventional
• Source: Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus
• Status: Completed
• Phase: Phase 1/Phase 2
• Start date: October 1, 2009
• Completion date: December 31, 2013