Tricuspid Valve Insufficiency Clinical Trial
Official title:
Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart
Right-sided heart disease has an important impact on the prognosis of patients with valvular heart disease. Up to now, Tricuspid Valve Regurgitation (TR) and right heart hemodynamics have not been extensively investigated. However, it is plausible that a significant degree of TR and the associated volume-overload of the right ventricle cause significant right ventricular wall stress. Although minor TR generally is well tolerated, major TR can lead to clinical symptoms, right ventricular dilatation and ultimately right ventricular heart failure. Up to now, the investigators do not dispose of any tools to diagnose and anticipate this unfavourable evolution. Nevertheless it is likely that right ventricular failure is preceded with a subclinical dysfunction of the right ventricle and a possibly reversible change in contractility of the myocardium. Recently, new techniques to evaluate the systolic function, the contractility and the hemodynamics of the heart have become available. First, this study will help us assessing the feasibility and accuracy of several imaging modalities in right-sided heart pathology with focus on TR and right heart myocardial performance. Second, this study will contribute to a better understanding of the hemodynamic effect of volume-overload and/or pressure-overload of the right ventricle. It will clarify the behaviour of TR, the evolution of right ventricular myocardial contractility and dysfunction during exercise and its impact on exercise capacity. By doing this, discrimination between well tolerated and ill-tolerated TR will be possible, thus identifying patients who might be eligible for treatment (medical, corrective, …).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06196684 -
Early Safety and Clinical Efficacy of Mitral Allograft in Tricuspid Surgery
|
||
| Not yet recruiting |
NCT03278418 -
Echo-Guided Tricuspid Valve Surgery Vs. Conservative Approach
|
N/A | |
| Terminated |
NCT03632967 -
Early Feasibility Study of the Percutaneous 4Tech TriCinch Coil Tricuspid Valve Repair System
|
N/A | |
| Active, not recruiting |
NCT05724225 -
"Atriogenic Tricuspid Selected, Omics Profile, Multimodality Imaging and Clinical Outcomes"
|
||
| Completed |
NCT02981953 -
TRI-REPAIR: TrIcuspid Regurgitation RePAIr With CaRdioband Transcatheter System
|
N/A | |
| Recruiting |
NCT04653428 -
German Registry for Transcatheter Tricuspid Valve Interventions
|
||
| Recruiting |
NCT02574650 -
Early Feasibility of the Mitralign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS) Also Known as TriAlign™.
|
N/A | |
| Completed |
NCT04945005 -
Prevention of Pacemaker Lead Induced Tricuspid regurgitAtion by Transesophageal eCho guidEd Implantation Registry
|
||
| Recruiting |
NCT03225612 -
Safety and Performance of the Trialign Percutaneous Tricuspid Valve Annuloplasty System (PTVAS)
|
N/A | |
| Completed |
NCT01585779 -
Contour 3D®/TriAd® Tricuspid Annuloplasty Ring Post-Market Clinical Trial
|
N/A | |
| Withdrawn |
NCT03166488 -
MRE Evaluation of Liver Stiffness After Tricuspid Valvular Repair
|
N/A | |
| Completed |
NCT03604484 -
Prophylactic Tricuspid Annuloplasty During Mitral Valve Surgery
|
N/A | |
| Completed |
NCT01537458 -
Long-term Outcome After Isolated Tricuspid Valve Repair
|
||
| Recruiting |
NCT05913908 -
EFS of the DUO System for Tricuspid Regurgitation (TANDEM II)
|
N/A | |
| Recruiting |
NCT04436653 -
THE TRAVEL TRIAL: Transcatheter Right Atrial-ventricular Valve rEplacement With LuX-Valve
|
N/A | |
| Completed |
NCT01334801 -
Biomarkers in Aortic Stenosis - B.A.S.S.
|
||
| Recruiting |
NCT04735003 -
Transcatheter Interventions for Tricuspid Insufficiency in Italy
|
||
| Recruiting |
NCT02314897 -
Left Ventricular Pacing to Prevent Iatrogenic TR Pilot Study
|
N/A | |
| Completed |
NCT01532921 -
EASE TRICUSPID Expertise-based Assessment Study on Clinical Efficacy of Contour 3D® in TRICUSPID Valve Annuloplasty
|
||
| Active, not recruiting |
NCT04614402 -
Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System
|