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Tricuspid Regurgitation clinical trials

View clinical trials related to Tricuspid Regurgitation.

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NCT ID: NCT04433065 Recruiting - Clinical trials for Tricuspid Regurgitation

TTVR Early Feasibility Study

Start date: October 20, 2020
Phase: N/A
Study type: Interventional

The objective of this early feasibility study is to gain early clinical insight into the performance of the Intrepid transcatheter tricuspid valve replacement (TTVR) system intended for transfemoral access to deliver a self-expanding bioprosthetic valve within the tricuspid valve.

NCT ID: NCT04345796 Recruiting - Clinical trials for Tricuspid Regurgitation

Pharmacological Reduction of Right Ventricular Enlargement

PROVE
Start date: February 15, 2021
Phase: Phase 3
Study type: Interventional

Functional tricuspid regurgitation (TR) has been regarded as a secondary phenomenon of heart failure (HF), mitral valve (MV) disease or atrial fibrillation. Regardless of left ventricular (LV) function or pulmonary artery pressure, presence of moderate or greater functional TR is associated with poor prognosis. When a patient develops functional TR, it causes RV dilation and tricuspid annular enlargement, which also lead to deterioration of TR. A vicious cycle of significant TR, RV volume overload, tricuspid annular dilation and consequent aggravation of TR is accepted as a main determinant of the poor clinical outcome of patients with TR. Therefore, therapies that induce reverse remodeling of the RV and consequently reduce TR, may improve clinical outcomes. However, there have been no proven medical therapies for TR. The investigators hypothesize that carvedilol or empagliflozin is effective on improving RV remodeling in patients with functional severe TR and try to examine this hypothesis in a multicenter, 2x2 factorial, and randomized comparison study using cardiac MRI.

NCT ID: NCT04339192 Recruiting - Clinical trials for Tricuspid Regurgitation

Minimally Invasive Tricuspid Surgery vs Medical Treatment for Severe TR

Start date: May 1, 2020
Phase: N/A
Study type: Interventional

Late tricuspid regurgitation (TR) is a common complication after left-sided valve surgery (LSVS), which usually progresses slowly and results in right heart failure at terminal stage. Over the past 3 decades, with the advances in minimally invasive surgical techniques, operative mortality after reoperation for severe TR has significantly decreased from 30% to 3-8%, leading to a gradual shift from medical therapy alone to surgery in those patients. However, there has been no consensus on the clinical benefit of minimally invasive tricuspid surgery over medical therapy for severe TR after LSVS.

NCT ID: NCT04097145 Recruiting - Clinical trials for Tricuspid Regurgitation

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

CLASP II TR
Start date: December 11, 2019
Phase: N/A
Study type: Interventional

To establish the safety and effectiveness of the Edwards PASCAL Transcatheter Repair System in patients with symptomatic severe tricuspid regurgitation who have been determined to be at an intermediate or greater estimated risk of mortality with tricuspid valve surgery by the cardiac surgeon with concurrence by the local Heart Team

NCT ID: NCT04093297 Recruiting - Clinical trials for Tricuspid Regurgitation

Band Versus Ring for Tricuspid Regurgitation

Start date: January 1, 2021
Phase: N/A
Study type: Interventional

Tricuspid regurgitation is common in patients with heart valve disease, both flexible band and rigid ring annuloplasty can correct this anomaly. However, there is no data to address which one can bring more benefits to these patients with combined heart valve disease. This study aims to prospectively compare the efficacy and long term outcomes of flexible band versus rigid ring annuloplasty for the correction of tricuspid regurgitation.

NCT ID: NCT03692598 Recruiting - Clinical trials for Tricuspid Regurgitation

Study of Transcatheter Tricuspid Annular Repair

STTAR
Start date: December 2016
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the safety and performance of the MIA Minimally Invasive Annuloplasty Device in patients with chronic functional tricuspid regurgitation.

NCT ID: NCT02537769 Recruiting - Clinical trials for Tricuspid Regurgitation

Study of the Clinical Impact of Surgical Correction of Tricuspid Insufficiency in Implantable LVAD Patients

Start date: August 2015
Phase: N/A
Study type: Interventional

The use of implantable left ventricular assist devices (LVAD) has increased over the last decade; partly because the newer continuous flow pumps feature a smaller design and better durability. These pumps have shown improved outcomes for those patients who don't qualify for heart transplantation and receive the LVAD device as a permanent therapy or a bridge to heart transplantation. Despite these improved outcomes, procedure related length of hospitalization for LVAD implantation is still 2 or 3 times that of other heart surgery treatments. One important reason for this is that many people experience right ventricular dysfunction after LVAD implantation. Treatment options for this are limited. Many LVAD patients with right ventricular dysfunction also have tricuspid valve regurgitation (TR). This is the failure of the tricuspid valve (TV) to close completely so that blood leaks backwards. Some recent studies suggest that correction of the TV during LVAD implantation has improved survival for those with severe regurgitation. However, this has not been evaluated for mild or moderate regurgitation. The goal of this study is to look at the clinical impact of surgical correction of mild to moderate TR in participants who are also undergoing LVAD implantation. The study will look at the degree of TR at various time points post-surgery, as well as any major cardiac adverse events, duration of hospitalization, and quality of life. The investigators hope to show that surgical correction of mild to moderate TR in LVAD patients will reduce right ventricular dysfunction and have a positive impact on health outcomes.

NCT ID: NCT00419354 Recruiting - Clinical trials for Tricuspid Regurgitation

The Impact of Right Ventricular Pacing on Tricuspid Regurgitation

Start date: March 2007
Phase: N/A
Study type: Observational

"1" To examine whether right ventricular pacing has an impact on tricuspid regurgitation grade that is related to pacing rather than to valve closure interference by the electrode.