Trichuriasis Clinical Trial
— ALBvLEVOfficial title:
Longitudinal Study of Efficacy of Standard Albendazole Treatment Versus Levamisole/Pyrantel Pamoate on Soil Transmitted Helminth Infections
Field epidemiological studies undertaken during 2005 in four village locations in Northern
Unguja, Zanzibar examined mothers and their pre-school aged children for helminth
infections.
The prevalence of Ascaris lumbricoides was found to have remained relatively high despite
community-wide treatment with the mass administration of Albendazole (a WHO recommended
de-wormer) in coordination with community vitamin A supplementation.
One hypothesis for this is that the children and mothers had Ascaris infections more
tolerant to Albendazole that subsequently failed to clear. It is necessary to compare the
present drug efficiency of Albendazole (first-line de-wormer) with Levamisole (second-line
de-wormer) on STH infections such patients a case-control setting to shed light on the
putative resistance of local Ascaris/Trichuris to albendazole.
In so doing, this should clarify whether there is resistance developing towards Albendazole
and have possible implications for introducing combination therapies of Levamisole and
Albendazole for first line de-worming mothers and their children in the future.
Status | Completed |
Enrollment | 20 |
Est. completion date | September 2007 |
Est. primary completion date | September 2006 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 1 Year to 45 Years |
Eligibility |
Inclusion Criteria: - Presently with soil-transmitted helminthiasis Exclusion Criteria: - absence of soil-transmitted helminthiasis |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Tanzania | Helminth Control Laboratory Unguja | Stone Town |
Lead Sponsor | Collaborator |
---|---|
Natural History Museum, United Kingdom | Ministry of Health, Tanzania, University of London |
Tanzania,
Stothard JR, Imison E, French MD, Sousa-Figueiredo JC, Khamis IS, Rollinson D. Soil-transmitted helminthiasis among mothers and their pre-school children on Unguja Island, Zanzibar with emphasis upon ascariasis. Parasitology. 2008 Oct;135(12):1447-55. doi — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clearance of STH faecal eggs in patient stool | 18 days | No |
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