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Treatment Strategy clinical trials

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NCT ID: NCT04464434 Recruiting - Systemic Sclerosis Clinical Trials

Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis

UPSIDE
Start date: September 17, 2020
Phase: Phase 4
Study type: Interventional

HSCT has been implemented in (inter)national treatment guidelines for diffuse cutaneous systemic sclerosis (dcSSc) and is offered in clinical care and reimbursed by national health insurance in several European countries. However, data and specific guidelines on the best timing of HSCT in the course of dcSSc are lacking. In particular, it is unclear whether HSCT should be positioned as upfront therapy or as rescue treatment for patients not responding to conventional immunosuppressive therapy. This multicentre, randomized, open label trial aims to compare two treatment strategies used in usual care: upfront autologous HSCT versus usual care with (intravenous (i.v.) cyclophosphamide (CYC) pulse therapy followed by mycophenolate mofetil (MMF) and HSCT as rescue option).

NCT ID: NCT03153865 Recruiting - Clinical trials for Unruptured Cerebral Aneurysm

New Therapeutic System of Unruptured Intracranial Aneurysms Based on Big Data From Chinese Population

NATIONAL-1
Start date: June 2, 2017
Phase: N/A
Study type: Observational

This is a prospective, multicenter, observational study, aiming at comparing the Safety and effectiveness among the different surgical treatment of unruptured intracranial aneurysms in China, so as to improve the diagnosis and treatment of unruptured intracranial aneurysms.