Clinical Trials Logo
  1. Home
  2. Treatment Side Effects
  3. NCT05098171

Study on Signal Switch Receptor Modified TIL for the Treatment of Advanced Gynecologic Tumors

Treatment Side Effects Clinical Trial

Official title:
A Clinical Study on Signal Switch Receptor Modified TIL for the Treatment of Advanced Gynecologic Tumors

Clinical Trial Summary

This study is to investigate the safety and efficacy of signal switch receptor modified TIL (GC201 TIL) in patients with advanced gynecologic tumors. Autologous TILs from tumor resections or biopsies are first gene modified(TGF-β receptor or PD-1 gene modified TILs which could transfer the suppression signal surrounding the microenvironment of tumor bed into persistent T cell activation signal) and than expanded before i.v. infusion into the patient after NMA lymphodepletion treatment with hydroxychloroquine(600mg,single-dose) and cyclophosphamide.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05098171
Study type Interventional
Source Shanghai Juncell Therapeutics
Contact Clinical GC
Phone 086-18001759113
Email clinicaltrials@juncell.com
Status Recruiting
Phase Early Phase 1
Start date September 26, 2021
Completion date September 25, 2025
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05098184 - Study on TIL for the Treatment of Advanced Melanoma Early Phase 1
Recruiting NCT05098197 - Study on TIL for the Treatment of Advanced Hepatobiliary-Pancreatic Cancers Early Phase 1
Not yet recruiting NCT03807388 - ReMindCare App for Patients From First Episode of Psychosis Unit. N/A
Recruiting NCT06057350 - Surgery Versus Endoscopic Resection for Incompletely Removed Early Colon CAnceR N/A
Recruiting NCT05084625 - PACED-digitized Support During Adjuvant Endocrine Therapy N/A
Recruiting NCT05092074 - Sofosbuvir/Velpatasvir/Voxilaprevir (SOF/VEL/VOX) for Patients With Hepatitis C Virus Infection
Active, not recruiting NCT04986670 - NutriCare Plus a Medically Tailored Meal Intervention Among Patients With Lung Cancer N/A
Recruiting NCT05142475 - Study on TIL for the Treatment of Advanced Breast Cancer Early Phase 1
Completed NCT04913350 - Contralateral Effects of Russian Current on Adolescent Athlete N/A
Terminated NCT04004884 - Liver Safety Assessment During Ulipristal Acetate Treatment for Uterine Fibroids (LISA)
Recruiting NCT04768582 - Platelet Reactivity After an Eastern Asian Loading Dose of Prasugrel in Taiwanese ACS Patients N/A
Recruiting NCT05767866 - Assessing an Oral EGFR Inhibitor,YK-209A in Patients Who Have Advanced Non-small Cell Lung Cancer With EGFR Phase 1/Phase 2
Recruiting NCT06340516 - NT-proBNP to Assess Trastuzumab-induced Cardiotoxicity N/A
Recruiting NCT06315582 - Surgical Approach to Uterine Septum N/A
Recruiting NCT05468307 - Study on TIL Engineered With Membrane-Binding Cytokine for the Treatment of Advanced Gynecologic Tumors Early Phase 1
Not yet recruiting NCT05085808 - RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Phase 4
Recruiting NCT04923100 - Therapeutic Effect of New Biologics in Crohn's Disease
Recruiting NCT05446051 - Development and Testing of a TTDSS for Cancer Patients N/A
Recruiting NCT05030701 - Toxicity of Treatments for Non-tuberculous Mycobacterial Infections in Cancer Patients or Not
Recruiting NCT05492487 - A Pilot Study on Fertility Conservative Treatment of Atypical Endometrial Hyperplasia in Singapore Phase 2