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Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy — DNS-ECT  

Treatment Resistant Depression Clinical Trial

Official title:
Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Clinical Trial Summary

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Clinical Trial Description

Graph-based network analyses of electroencephalographic (EEG) signals allow characterization of functional networks. The robustness of local networks to disruption is quantified as local efficiency (Elocal), while network integration is quantified as global information transfer (Eglobal). Aim 1: Assess relationships between sleep slow-wave activity (SWA) and awake Elocal over the course of ECT. Aim 2: Quantify relationships between depression severity and awake Elocal over the course of ECT. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05905705
Study type Observational
Source Washington University School of Medicine
Contact Robby Greenspan
Phone 314-273-6129
Email greenspan@wustl.edu
Status Recruiting
Phase
Start date March 7, 2023
Completion date July 31, 2027
View Details
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