Drug Resistance, Multiple Clinical Trial
Official title:
A Multicentre Intervention Study on the Use of Hand Sanitizers in the Prevention of Intestinal Colonization With Extended-spectrum Beta-lactamase-producing Enterobacteriaceae in Travellers to the Indian Subcontinent
Travelling to tropical and subtropical countries is a known risk factor for becoming
colonized with extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae.
Especially travellers returning from the Indian subcontinent show high colonization rates of
up to almost 90%.
While risk factors for becoming colonized have been identified in several studies, no
preventive measure has been tested so far.
One of the factors associated with becoming colonized while travelling is suffering from
travellers' diarrhoea. Earlier studies looking at diarrhoea in childhood as well as school
and/or work absenteeism because of diarrhoeal diseases have shown protective effects through
good hand hygiene. Furthermore, a recent retrospective study has shown lower rates of
travellers' diarrhoea in people using hand gel sanitizers. Improving hand hygiene in
travellers through increased hand washing and the use of hand gel sanitizers might therefore
not only decrease the rate of travellers' diarrhoea but the carriage rate with ESBL-producing
Enterobacteriaceae as well. However, there is no prospective data available to prove the
usefulness of such an intervention, neither in the prevention of travellers' diarrhoea nor in
the prevention of colonization.
In the current study, investigators plan to compare colonization rates with ESBL-producing
Enterobacteriaceae in travellers receiving pre-travel advice on improved hand hygiene
(including the use of hand gel sanitizers) with travelers receiving standard advice.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03339947 -
French Travelers' Knowledge of Risk of Acquiring ESBL-PE
|
N/A | |
| Completed |
NCT02625129 -
Effectiveness of and Satisfaction With a Pharmacist-managed Travel Medicine Clinic
|
N/A |