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An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA

Trauma Clinical Trial

Official title:
An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA

Clinical Trial Summary

The immediate goal of the proposed research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress. The standing CT scanner holds promise for detecting arthritic changes earlier than other imaging modalities because of the combination of its 3D nature and ability to image joints in a weight-bearing pose. A secondary goal of the proposed research is to enable predictive models for osteoarthritis risk based on measures of post treatment contact stress, both to inform treatment and so that new interventions can be tested in a manner incorporating risk stratification.

Clinical Trial Description

Individuals who present with an intra-articular of the tibial plafond will be consented to participate in this study. We will obtain pedCAT scans at 6, 12, and 18 months post-injury, as well as several questionnaires that will be administered during the clinical visits. We will also review the subjects' electronic medical record for data related to the injury, including the timing and mechanism of injury, time from injury to surgery, length of hospital stay, any complications and/or subsequent ankle surgeries, as well as any clinic notes, imaging, and/or outcomes scores related to the calcaneus fracture. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03809520
Study type Interventional
Source University of Iowa
Contact Catherine Fruehling, BA
Phone 3194678256
Email catherine-fruehling@uiowa.edu
Status Recruiting
Phase N/A
Start date January 1, 2017
Completion date December 30, 2024
View Details
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