Trauma Clinical Trial
Official title:
The Impact of Chemotherapy on Memory Function and the Development of Traumatic Symptoms in Children With Cancer
Background: While treatment for pediatric cancer has improved significantly over the past 40
years, the neurotoxic side-effects of the chemotherapy agents themselves are now being
recognized. Two drugs suspected of having acute impact on memory performance in children are
methotrexate (MTX) and steroids (GCs). In addition, new evidence suggests that this
neurotoxicity might actually protect these children from traumatization.
Working hypothesis and aims: This project aims to examine the acute impact of MTX and GC
chemotherapy on memory performance in children and young adults with cancer, and the
subsequent impact on the development of traumatic symptoms. We hypothesize that MTX and GCs
will each produce acute declines in memory performance and that children with greater
reductions in memory performance will have fewer traumatic symptoms.
Methods: The investigators will recruit 45 children being treated with MTX or GCs at Dana
Children's Hospital. To determine acute impact on memory, a battery of memory tests will be
administered before and after a cycle of MTX and before and after a cycle of GCs. In
addition, traumatic symptoms will be assessed at each post-chemotherapy evaluation point
Expected results: The investigators expect poorer memory performance after MTX and after GCs
and that these performance declines will correlate with lower rates of traumatic symptoms.
Importance: The immediate impact of MTX and GCs on memory is not well known, especially in
children. In addition, recent findings have led us to hypothesize that chemotherapy-induced
deficits in memory function would paradoxically protect these patients from the
traumatization often associated with cancer and its treatment. The proposed study will test
this novel hypothesis for the first time.
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04848376 -
Post-Market Clinical Follow-up Study of A-SPINE's Products
|
||
| Terminated |
NCT03781817 -
Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children With Non-operative Fractures
|
Phase 4 | |
| Completed |
NCT04342416 -
Using a Brief Visuospatial Interference Intervention to Reduce Intrusive Memories Among Trauma Exposed Women
|
N/A | |
| Recruiting |
NCT04856449 -
DBT Skills Plus EMDR for BPD and Trauma
|
N/A | |
| Completed |
NCT04356963 -
Adjunct VR Pain Management in Acute Brain Injury
|
N/A | |
| Completed |
NCT05669313 -
The Effects of Hypothermia and Acidosis on Coagulation During Treatment With Rivaroxaban Measured With ROTEM
|
||
| Active, not recruiting |
NCT03622632 -
Pilot Study to Measure Uric Acid in Traumatized Patients: Determinants and Prognostic Association
|
||
| Recruiting |
NCT04725721 -
Testing FIRST in Youth Outpatient Psychotherapy
|
N/A | |
| Active, not recruiting |
NCT05530642 -
An Augmented Training Program for Preventing Post-Traumatic Stress Injuries Among Diverse Public Safety Personnel
|
N/A | |
| Not yet recruiting |
NCT05649891 -
Checklists Resuscitation Emergency Department
|
N/A | |
| Not yet recruiting |
NCT03696563 -
FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS
|
N/A | |
| Withdrawn |
NCT03249129 -
Identification of Autoantibodies and Autoantigens in the Cerebrospinal Fluid of Patients With Spinal Cord Trauma
|
||
| Completed |
NCT02240732 -
Surgical Tourniquets and Cerebral Emboli
|
N/A | |
| Completed |
NCT02227979 -
Effects of PURPLE Cry Intervention
|
N/A | |
| Withdrawn |
NCT01169025 -
Fentanyl vs. Low-Dose Ketamine for the Relief of Moderate to Severe Pain in Aeromedical Patients
|
N/A | |
| Recruiting |
NCT01812941 -
Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
|
N/A | |
| Completed |
NCT03112304 -
Child STEPS for Youth Mental Health in Maine Sustainability
|
N/A | |
| Completed |
NCT01475344 -
Fibrinogen Concentrate (FGTW) in Trauma Patients, Presumed to Bleed (FI in TIC)
|
Phase 1/Phase 2 | |
| Completed |
NCT01201863 -
Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy
|
Phase 4 | |
| Completed |
NCT01210417 -
Trauma Heart to Arm Time
|
N/A |