Transplantation Clinical Trial
Official title:
Hepatitis E Virus Infection in Pediatric Transplantation, a Prevalence Study
Hepatitis E virus (HEV) is an emerging disease. The genotype 1 and 2 are predominant in Asia
and Africa, and are responsible for recurrent epidemics. Genotype 3 is the main genotype
found in Europe and North America and is responsible for sporadic infections except for
travel associated diseases.
HEV had a principally asymptomatic form. However, it was recently demonstrated that it could
lead to a chronic form, especially in immunosuppressed patients. Moreover, in liver
transplanted patients the infection could mimic a rejection and lead to the loss of the
transplant. In other immunosuppressed patients, chronic hepatitis lead to cirrhosis and its
well-known complications (ascitis, digestive hemorrhage, liver failure...). There is a lack
of information about the prevalence of this disease.
In Canada the incidence of HEV infection was high (15-86% for liver transplanted children
with liver tests disturbed). In Germany the prevalence was lower: 3,2% in liver & kidney
transplanted children whereas 7,4% in control. It was shown in a retrospective study that in
liver (and liver+kidney) transplanted children the prevalence in Lyon was around 8,3%.
This study will determined in a prospective approach the HEV prevalence in kidney, lung,
heart and bone marrow transplanted children in Lyon.
n/a
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