Kidney Transplantation Clinical Trial
Official title:
The Pharmacokinetics and Dosage Regimen of Sirolimus in a Cyclosporine or Tacrolimus-Based Immunosuppression in Renal Transplant Patients
The purpose of this study is to understand the pharmacokinetic of sirolimus in different regimens, as well as the dose-level relationship of cyclosporine and tacrolimus, and design the most appropriate cyclosporine/sirolimus/steroid or tacrolimus/sirolimus/steroid dose regimen for Taiwanese.
The dose and pharmacokinetic of an immunosuppressant may differ in different ethnics, and
different combinations.
The purpose of this study is to determine the dose-level relationship of sirolimus through
pharmacokinetic study. The dose-level relationship of cyclosporine and tacrolimus was also
assessed. From clinical outcome and blood level of sirolimus and cyclosporine or tacrolimus,
we can design the most appropriate cyclosporine/sirolimus/steroid or
tacrolimus/sirolimus/steroid dose regimen for Taiwanese.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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