Epidural vs. Wound Catheter Following Liver Resection

Transplant Surgery Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03638401
• Other study ID #: RL14/11048
• Status: Completed
• Phase: N/A
• Start date: March 3, 2014
• Est. completion date: October 5, 2015

Study information

• Verified date: August 2018
• Source: The Leeds Teaching Hospitals NHS Trust
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Good postoperative pain control after any major surgery allows early mobilization, minimises postoperative complications and reduces patient distress. Multiple different methods of delivering analgesia have been described.

This study aims to compare postoperative pain control between patients with epidural analgesia versus the combination of continuous infiltration of local anaesthetic with wound catheters, TAP block and IV PCA with opiate analgesia following open liver resection. The investigators expect that pain control will be similar between the two groups but that the utilization of wound catheters will confer benefit due to the lack of systemic side effects associated with epidural analgesia

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: October 5, 2015
• Est. primary completion date: October 5, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

• All adult patients scheduled to undergo an open liver resection at this hospital will be eligible to participate.

Exclusion Criteria:

• Patients with a contraindication to either epidural or wound catheter

• Inability to give written, informed consent

• Aged less than 18 years old

• Liver resection combined with a secondary surgical procedure

• Body mass index of <18 or >40

• Pregnancy or lactation

• A history of chronic pain requiring regular opioid analgesia

• Prisoners

Related Conditions & MeSH terms

• Transplant Surgery

Intervention

Procedure:
• This arm will received perioperative transversus abdominis plane (TAP) block followed by continuous infusion of local anaestheic by wound catheters and an IV morphine PCA.
This arm will received perioperative transversus abdominis plane (TAP) block followed by continuous infusion of local anaestheic by wound catheters and an IV morphine PCA.

Locations

Country	Name	City	State
United Kingdom	Leeds Teaching Hospitals NHS Trust	Leeds

Sponsors (1)

Lead Sponsor	Collaborator
The Leeds Teaching Hospitals NHS Trust

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The length of hospital stay following open liver resection		6 months (or length of the study)