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Transplant Rejection clinical trials

View clinical trials related to Transplant Rejection.

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NCT ID: NCT04046549 Completed - Clinical trials for Kidney Transplantation

A Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant

Start date: October 30, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to evaluate the efficacy, safety and tolerability of dual costimulation blockade with VIB4920 in combination of belatacept in adult male or female recipients of a renal allograft from a deceased, living unrelated or human leukocyte antigen (HLA) non-identical living related donor.

NCT ID: NCT03582436 Completed - Clinical trials for Kidney Transplantation

Rejection Diagnosis in Kidney Transplants Patients

KTD-innov
Start date: June 25, 2018
Phase:
Study type: Observational

Main objective: To constitute a prospective multicentre French cohort of kidney transplant recipients including clinical, biological and immunological evaluation combined with non-invasive biomarkers in peripheral blood and urine, and gene expression assessment in allograft biopsy in order to increase the performance of rejection diagnosis in kidney transplant patients. the investigators hypothesise that the addition of non-invasive biomarkers and intragraft assessment of gene expression profiles will improve the diagnosis capacity of histology in kidney transplant recipients as it reveals pathophysiological pathways that are not captured by light microscopy.

NCT ID: NCT01766050 Completed - Clinical trials for Transplant Rejection

Study to Evaluate Effect of Belatacept on Pharmacokinetics of Inje Cocktail in Healthy Volunteers

Start date: January 2013
Phase: Phase 4
Study type: Interventional

The purpose of this study is to determine the effects of belatacept on the pharmacokinetics of caffeine, losartan, omeprazole, dextromethorphan and midazolam

NCT ID: NCT01338779 Completed - Clinical trials for Kidney Transplantation

Study of Tolerant Kidney Transplant Recipients

FACTOR
Start date: May 2004
Phase: N/A
Study type: Observational

The purpose of this multi-center (observational) registry study is to establish a database of clinical and laboratory information that may help to identify any unique characteristics of tolerant participants that differ from participants who reject their kidney after discontinuing immunosuppressive drugs.

NCT ID: NCT01236378 Completed - Clinical trials for Renal Transplantation

Study To Evaluate Pharmacokinetics Of Sirolimus In Stable Renal Transplant Recipients

Start date: December 2010
Phase: Phase 1
Study type: Interventional

Sirolimus, 1 mg, white, triangular tablets (Rapamune®) was approved on 03 April 2007 in China for prophylaxis of organ rejection in renal transplantation. A pharmacokinetic (PK) study to be conducted in renal allograft recipients was requested by State Food and Drug Administration (SFDA) to provide further guidance for clinical use. To minimize risk to patients, this study is designed to collect blood PK samples from renal allograft recipients who are currently under sirolimus (1 mg tablets) treatment with or without concomitant medication(s). PK samples will be collected from these patients to characterize the steady state PK of sirolimus during sirolimus maintenance therapy. This study will not involve any changes to the established treatment regimen for the patients who enroll in the study