Transplant; Failure, Kidney Clinical Trial
Official title:
Effects of Sevoflurane and Desflurane Anesthesia on Regulatory T Cells in Patients Undergoing Living Donor Kidney Transplantation
This prospective interventional study aims to compare sevoflurane and desflurane anesthetic agents on regulatory T cell (Treg) numbers and its cytokine production in patients undergoing Living Donor Kidney Transplant (LDKT).
All patients with end stage renal disease (ESRD) need renal replacement therapy, either
dialysis or kidney transplantation. Dialysis, despite its effectiveness in prolonging ESRD
patients' lives, is a burden. Successfulness in kidney transplantation will restore good
quality of life in ESRD patients. However, one of the most important complications that lead
to transplant failure is graft rejection. It is already known that the pathophysiology of
the rejection is immune response. Recent evidence showed that regulatory T cell (Treg) plays
a central role in preventing graft rejection by inhibiting recipient alloimmune response
(1-3). Characterization of Treg numbers and/or functional changes under various conditions
may lead to a new preventive measure and/or a novel therapeutic strategy for graft
rejection.
Kidney transplantation is conducted under general anesthesia. Interestingly, several agents
used in general anesthesia have also modulated immune functions (4-12). Although the effect
of inhalation anesthetic agents on leukocyte count has been shown, the effect on Treg
function has totally been unknown. Knowing the effects of inhalation agents on Treg numbers
and functions will be beneficial to intraoperative management during transplant surgery,
aiming toward reducing the risk of graft rejection in the future.
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