Clinical Trial Summary
Transient osteoporosis of pregnancy (TOoP) is uncommonly encountered in orthopedic and
obstetric practice, with most reports consisting of single cases.
This rare condition consists of significant osteoporosis affecting the hips and spine,
causing significant morbidity, and putting young female patients at risk for vertebral and
femoral neck fractures.
The pathogenesis of transient osteoporosis of pregnancy is unknown, with various theories as
to its etiology.
Recently, a number of reports have described elevated levels of PTHrP in patients with
transient osteoporosis in pregnancy and of the postpartum period Our goal in this study is
to assess the role of PTHrP in transient osteoporosis of pregnancy
