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Transfusional Hemosiderosis clinical trials

View clinical trials related to Transfusional Hemosiderosis.

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NCT ID: NCT01927913 Withdrawn - Metabolic Diseases Clinical Trials

Treatment of Iron Overload Requiring Chelation Therapy

Start date: November 20, 2014
Phase: Phase 2
Study type: Interventional

The purpose of this open-label study is to assess liver iron concentration using MRI imaging in subjects with beta-thalassemia when administered with either SPD602 or deferasirox for the treatment of chronic transfusional iron overload.

NCT ID: NCT01394029 Completed - Clinical trials for Transfusional Hemosiderosis

Observation of Patients With Transfusional Hemosiderosis Treatment With Deferasirox

Start date: July 2011
Phase: N/A
Study type: Observational

This study will observe patients with transfusional hemosiderosis treated with deferasirox in actual practice setting.

NCT ID: NCT00845871 Completed - Clinical trials for Transfusional Hemosiderosis

Palatability and Tolerability of Deferasirox Taken With Meals, With Different Liquids or Crushed and Added to Food

Start date: May 2009
Phase: Phase 4
Study type: Interventional

This single-arm, open-label, multi-center study enrolled 65 patients from approximately 20 centers. All patients who met the study criteria and were taking, beginning or resuming treatment with Deferasirox were allowed. The study will began with a one month run-in phase, where all patients were instructed to take Deferasirox according to their physician's prescribing information.

NCT ID: NCT00631163 Completed - Clinical trials for Transfusional Hemosiderosis

Efficacy and Safety of Deferasirox in Patients With Chronic Anemia and Transfusional Hemosiderosis

Start date: October 2007
Phase: Phase 2
Study type: Interventional

The overall purpose of this trial is to further evaluate the efficacy and safety of deferasirox, dosed initially according to the transfusional iron intake, in patients with transfusion dependant anemia related to disorders other than β-thalassemia and sickle cell disease. During the study, the dose will be adjusted based on serum Ferritin.The overall purpose of the extension is to allow further treatment of patients who have already completed the core study, and to enable collection of long term efficacy and safety data. Patients will continue to receive Deferasirox at the dose they received at the end of the core study.

NCT ID: NCT00600938 Completed - Clinical trials for Transfusional Iron Overload

Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload

CORDELIA
Start date: November 2007
Phase: Phase 2
Study type: Interventional

This is a clinical research study in patients who have iron overload in the heart due to chronic blood transfusions. The study will have 2 treatment groups and will compare the safety and efficacy of chelation therapy with a medicine called deferasirox (ICL670) with another medicine called deferoxamine (DFO). The study is aimed at finding out which of the two medicines is the best for treating iron overload in the heart. Patients will be treated for 12 months (core study phase). Patients who complete the core study phase will be offered to continue their study treatment in a 12 months extension phase. During the core and extension, the effects of treatment on iron overload in the heart and the liver will be evaluated using specific magnetic resonance imaging (MRI) assessments.