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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04963101
Other study ID # ZDWY.CSYGJWK.003
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date June 25, 2021
Est. completion date June 30, 2022

Study information

Verified date July 2021
Source Fifth Affiliated Hospital, Sun Yat-Sen University
Contact Ning Jiang, M.D
Phone +86 15653868023
Email jiangn57@mail2.sysu.edu.cn
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

In this study, we planned to identify transcriptome expression profiles (circRNAs, lncRNAs, and mRNAs) from peripheral blood mononuclear cells (PBMCs) of 30 patients with OPLL and 30 other non-OPLL patients by high-throughput sequencing.Sequence analysis was used to predict miRNAs that might bind circRNAs and lncRNAs.Through bioinformatics analysis, competitive endogenous RNAs (cerRNAs), as well as coexpression networks among circRNAs, lncRNAs, miRNAs, and mRNAs, were constructed to provide key molecules and signaling pathways associated with OPLL.


Recruitment information / eligibility

Status Recruiting
Enrollment 30
Est. completion date June 30, 2022
Est. primary completion date June 25, 2022
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: 1. Voluntarily participate in the clinical study and sign the informed consent; 2. All OPLL patients meet the diagnostic criteria set out in the JOA Clinical Practice Guidelines for Spinal Ligament Osification 2019; 3. Age =18, gender unlimited; 4. All non-OPLL patients and healthy volunteers have no serious diseases of the heart, lung, brain, liver, kidney and blood system, such as autoimmune diseases, tumors, psychosis, infectious diseases, etc., and have no bad habits or recent history of taking special drugs. Exclusion Criteria: 1. Unable to sign the informed consent; 2. Patients who do not meet the inclusion criteria or diagnostic criteria; 3. <18 years old; 4. Women planning to become pregnant/lactating/pregnant; 5. Complicated with serious heart, lung, brain, liver, kidney, blood system diseases, such as autoimmune diseases, tumors, mental illness, infectious diseases, drug addiction and other bad addicts;Those who have recently taken special drugs; 6. Individuals who do not agree to donate peripheral blood or who are obviously uncomfortable with drawing blood.

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
China Facility Zhuhai Guangdong

Sponsors (1)

Lead Sponsor Collaborator
Fifth Affiliated Hospital, Sun Yat-Sen University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary circRNA, lncRNA, mRNA 1 year
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