Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Other |
Facial cleanliness |
Trained graders will assess facial cleanliness for all children 6 months to 9 years old. The main attributes of facial assessments include presence/lack of ocular and nasal discharge, as well as the time of day of the assessment. |
Up to 12 months |
|
Other |
Community awareness of the MDA campaign |
A cross-sectional study design will be used to evaluate the impact of the mobilization activities aimed to raise the community's knowledge and awareness of the upcoming MDA campaign. |
Up to 12 months |
|
Primary |
Coverage Among Young Children |
Feasibility of enhanced antibiotic regimens will be assessed as antibiotic coverage during each of the subsequent treatment rounds, allowing for the calculation of the number of doses each participant received. The definition of coverage for this study is the number of individuals ages 6 months to 9 years who received the drug in study villages in each treatment round divided by number of children ages 6 months to 9 years enumerated in the baseline census. MDA coverage will be further validated through use of the WHO's Supervision Coverage Tool. |
Up to 12 months |
|
Primary |
Number of Participants Missing Antibiotic Treatment Round |
Compliance with the enhanced antibiotic regimens will be assessed as the extent of missed rounds of antibiotic treatment. |
Up to 12 months |
|
Primary |
Acceptability |
The acceptability of enhanced antibiotic regimens will be assessed through focus group discussions which are led by a trained qualitative researcher using a guided discussion tool. Discussion topics include perceptions of trachoma disease and treatment, perception of the MDA campaigns, and community mobilization. This qualitative assessment will not generate a summary score. |
Up to 12 months |
|
Primary |
Cost |
The cost of enhanced antibiotic regimens will be compared to each other and compared to the standard-of-care, annual MDA. The researchers will examine both financial costs (expenditures from the implementation of the intervention), and economic costs (full value of the resources used to implement the intervention). Cost data will be categorized under the following categories: capital costs, medical personnel costs, non-medical personnel costs, commodities, field consumable costs, and lab costs as informed by previous studies. |
Up to 12 months |
|
Secondary |
Prevalence of C. trachomatis Infection |
Children age 6 months to 9 years selected for the study will receive ocular swabbing for C. trachomatis infection. The conjunctival epithelial specimen will be used for polymerase chain reaction (PCR) analysis in the lab. |
Up to 12 months |
|
Secondary |
Prevalence of Clinical Trachoma by Field Grader |
A field grader will assess both eyes of each child age 6 months to 9 years selected for the study. The grader will note their assessment of trachoma grade prior the ocular swab being obtained. |
Up to 12 months |
|
Secondary |
Prevalence of Clinical Trachoma by Photograph |
Tarsal conjunctivae photographs will be taken of both eyes of each child age 6 months to 9 years selected to provide an ocular swab for the study. Images will be sent to a grading center located off-site to be graded by a designated standard grader. |
Up to 12 months |
|
Secondary |
Coverage Among Older Children and Adults |
Feasibility of enhanced antibiotic regimens will be assessed as antibiotic coverage during each of the subsequent treatment rounds, allowing for the calculation of the number of doses each participant received. The definition of coverage for this secondary analysis is the number of individuals aged 10 to 15 years, and the number of persons greater than 15 years old who received the drug in study villages in each treatment round divided by number of individuals in each age group enumerated in the baseline census. |
Up to 12 months |
|