Clinical Trials Logo
  1. Home
  2. Tourette's Disorder
  3. NCT01585207

Proof-of-Concept Safety Study of CPP-109 (Vigabatrin) for Treatment Refractory Tourette's Disorder

Tourette's Disorder Clinical Trial

Official title:
Open Label Safety and Tolerability Trial of CPP-109 (Vigabatrin) in Adults With Treatment Refractory Tourette's Disorder

Clinical Trial Summary

The purpose of this study is to determine if vigabatrin, an unusual anti-seizure medication, will diminish the Tourette Disorder outbursts in young adults whose symptoms have persisted into adulthood and have not responded to usual treatment.

Clinical Trial Description

The aims of this study are to 1) explore proof of concept that CPP-109 will reduce tics, and 2) to obtain systematic data regarding dosing, safety and tolerability of CPP-109 in adults with treatment refractory TD. We will obtain preliminary data on estimate of effect size for tics using Cohen's d, calculating the difference between the two means (baseline and endpoint scores on the YGTSS), divided by the standard deviation of the difference. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01585207
Study type Interventional
Source Icahn School of Medicine at Mount Sinai
Contact
Status Completed
Phase Phase 1/Phase 2
Start date July 2012
Completion date March 2015
View Details
See also
  Status Clinical Trial Phase
Completed NCT02316145 - Internet-based Coaching for Young Adults With Neuropsychiatric Disorders N/A
Completed NCT00706589 - Aripiprazole in Children and Adolescents With Chronic Tic Disorder or Tourette's Disorder Phase 3
Completed NCT01416441 - Safety and Tolerability Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Phase 3
Completed NCT01727700 - Study Evaluating the Safety and Efficacy of Fixed-dose Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Phase 3
Recruiting NCT06408662 - Remote Delivery of a Mindfulness-based Intervention for Tics N/A
Completed NCT01315327 - Omega-3 Fatty Acids in Tourette's Disorder N/A
Completed NCT01795105 - ABF Tourette's Disorder Post Marketing Surveillance Study
Completed NCT01418339 - Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Phase 3
Completed NCT01727713 - Safety and Tolerability of Once-daily Oral Aripiprazole in Children and Adolescents With Tourette's Disorder Phase 3
Completed NCT03042507 - Psychosocial Intervention for Young Children With Chronic Tics N/A
Completed NCT03508245 - Investigating Circadian Rhythms in Youth With Persistent Tic Disorders N/A
Completed NCT02864589 - Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder N/A
Completed NCT02413216 - TicHelper: A Computerized Comprehensive Behavioral Intervention for Tics (CBIT) N/A
Completed NCT01177774 - Assessment of Children With Tic Onset in the Past 6 Months
Completed NCT01418352 - Efficacy & Safety Study of Once-weekly Oral Aripiprazole in Children and Adolescents With Tourette's Disorder (TD) Phase 3
Recruiting NCT05499741 - Forehead Temperature-Regulating Therapy for Insomnia in Adults With Tourette's Disorder N/A
Completed NCT03916055 - Internet-delivered Behaviour Therapy for Children and Adolescents With Tourette's Disorder N/A