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Total Thyroidectomy clinical trials

View clinical trials related to Total Thyroidectomy.

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NCT ID: NCT04212533 Completed - Total Thyroidectomy Clinical Trials

Preoperative Hypocalcaemia, a Comparative Clinical Trial

professor
Start date: January 1, 2018
Phase: N/A
Study type: Interventional

two groups of patients undergoing total thyroidectomy one group received calcium and vit d prophylaxis the other group received no prophylaxis the investigator measured calcium level post and preoperative and development of tetant was recorded

NCT ID: NCT03276988 Completed - Total Thyroidectomy Clinical Trials

Tolerability, Safety and Pharmacokinetics Study of GX-30 in Total Thyroidectomy or Near Total Thyroidectomy Patients

Start date: September 7, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

This study is designed as a combination of phase 1 (Part A) and phase 2 (Part B). The purpose of Part A was to determine the safety, tolerability, and pharmacokinetics in patients with total thyroidectomy or near total thyroidectomy of GX-30 and it has been completed. The Part B is currently recruiting and will investigate the efficacy and safety of GX-30 compared with THYROGEN®.

NCT ID: NCT02167529 Completed - Total Thyroidectomy Clinical Trials

Quality of Life After Thyroidectomy (ThyrQol)

ThyrQol
Start date: March 6, 2014
Phase: N/A
Study type: Observational

The purpose of this study is to evaluate the evolution of quality of life and voice function with different questionnaires (VIH, SF36) before and after total thyroidectomy.

NCT ID: NCT02089542 Completed - Total Thyroidectomy Clinical Trials

Intra-operative Infra-red Fluorescent Imaging in Thyroid and Parathyroid Surgery

Start date: October 2014
Phase: Phase 1/Phase 2
Study type: Interventional

Reliable identification of parathyroid glands is critical to the success of thyroid and parathyroid surgery. In thyroid surgery, inadvertent injury to parathyroid glands may cause temporary or permanent hypoparathyroidism (low calcium levels needing long term treatment). In parathyroid surgery, early identification of normal and/or enlarged parathyroid glands helps in deciding on the extent of surgery and increases the chances of postoperative normal calcium levels. Methylene Blue (Methylthioninium chloride, MB) is a dye that when given intravenously in high doses, is taken up differently by thyroid and parathyroid tissue. It is currently used during parathyroid surgery by some surgeons to help identify enlarged parathyroid glands by visual examination alone. Such visual examination is unhelpful in the identification of 'normal' parathyroid tissue. MB exhibits fluorescent properties in the near-infrared range (light just beyond the visible spectrum). This can be picked up by an appropriate imaging system. This has potential to identify and differentiate between 'normal' parathyroid, 'abnormal' parathyroid and thyroid tissue during surgery. The investigators have established the feasibility of the intra-operative use of a near infra-red fluorescent imaging device called Fluobeam® and demonstrated the ability of this device to pick up near infra-red fluorescence from human tissue after administration of intravenous MB. Animal experiments have shown that doses as low as 0.1mg/kg of MB given intravenously enable fluorescent visualisation of thyroid and parathyroid glands. This study will aim to optimise the dose and timing of administration of MB in human thyroid and parathyroid surgery and to develop a protocol which would then subsequently be assessed for effectiveness in a multi-centred randomized controlled setting.