Biochemical Approach to Measuring Surgical Trauma

Status Withdrawn

Clinical Trial Summary

This study will examine the magnitude and time course of changes in circulating (serum and plasma) biomarker concentrations associated with musculoskeletal injury created by total knee replacement surgery. The sensitivity to injury will be characterized by the changes in mean serum concentration before and after surgery. Specificity for the injured state will be evaluated comparing the baseline to peak change (injury response) with the pre-surgery to follow-up baseline fluctuation (i.e. measurement noise).

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Total Knee Replacement

Clinical Trial Details

NCT number	NCT01037400
Study type	Observational
Source	McMaster University
Contact
Status	Withdrawn
Phase	N/A
Start date	February 2010

View Details

See also
Status	Clinical Trial	Phase
Terminated	`NCT04040985` - Legion Primary Safety and Efficacy	N/A
Recruiting	`NCT05279092` - Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study	Phase 2
Completed	`NCT03286543` - Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty Using the SPRINT Beta System	N/A
Not yet recruiting	`NCT04594447` - Physica System KR vs Physica System CR (K-20)	N/A
Completed	`NCT02413996` - Effects of Virtual Reality Rehabilitation in Patients With Total Knee Arthroplasty	N/A
Completed	`NCT01500252` - Patellar Resurfacing Versus Patellar Retention in Total Knee Arthroplasty - A Randomized Clinical Trial	Phase 4
Completed	`NCT04081493` - The Efficacy of Low-load Blood Flow Restricted Resistance Before TKR	N/A
Active, not recruiting	`NCT03339557` - Comparison of Three Knee Replacements	N/A
Enrolling by invitation	`NCT04513145` - Adductor Canal Block	Phase 2/Phase 3
Completed	`NCT06045078` - Aromatherapy in Total Knee Replacement	N/A
Completed	`NCT02468934` - Electrical Stimulation for the Treatment of Pain Following Total Knee Arthroplasty (TKA) Using the SPRINT System	N/A
Completed	`NCT02914210` - Virtual vs. Traditional Physical Therapy Following Total Knee Replacement	N/A
Withdrawn	`NCT01523418` - Study to Observe Safety of Xarelto in VTE Prophlylaxis After Elective TKR (Total Knee Replacement) or THR (Total Hip Replacement)	N/A
Completed	`NCT00795223` - Comparative Pain Control Between 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for FNB After TKA	Phase 4
Completed	`NCT01307202` - Morphine Consumption in Joint Replacement Patients, With or Without Gabapentin Treatment	N/A
Completed	`NCT01515449` - Predictors of Poor Outcomes in 1038 Sigma Knees	N/A
Completed	`NCT01522781` - 10 Year Outcome of Total Knee Replacement (TKR) Using Sigma Prosthesis	N/A
Completed	`NCT04166539` - Neurotoxicity and Cardiotoxicity in Total Joint Arthroplasty
Completed	`NCT03454256` - Virtual Reality Rehabilitation in Patients With Total Knee Replacement	N/A
Enrolling by invitation	`NCT06118073` - Effect of Mindfulness on Pain After Total Knee Arthroplasty	N/A