Epidural Morphine for Postoperative Analgesia After Total Knee

Status Completed

Clinical Trial Summary

Single femoral nerve blockade combined with patient-controlled intravenous analgesia are used for postoperative analgesia for patients after TKA in the hospital of the investigators. Although this method provides acceptable analgesia, the incidence of opioid-associated side effects is relatively high. Low-dose epidural morphine is commonly used in postoperative analgesia after cesarean section, and the effect of single dose morphine lasts more than 20 hours, with low incidences of itching, nausea, vomiting, and respiratory depression. The investigators hypothesize that, for patients undergoing TKA, the addition of low-dose epidural morphine to single femoral nerve block and intravenous opioids can improve the postoperative analgesia, reduce the consumption of intravenous opioids and decrease opioid-associated side effects.

Clinical Trial Description

Total knee arthroplasty (TKA) is an important therapy for patients with serious knee osteoarthritis in order to improve quality of life and relieve pain. But a large number of patients who undergo this surgery experience moderate to severe postoperative pain. Previously, the investigators used single femoral nerve blockade combined with patient-controlled intravenous analgesia for postoperative analgesia for patients after TKA. Although this method provides acceptable analgesia, the incidence of opioid-associated side effects is relatively high. Low-dose epidural morphine is commonly used in postoperative analgesia after cesarean section, and the effect of single dose morphine lasts more than 20 hours, with low incidences of itching, nausea, vomiting, and respiratory depression. The investigators hypothesize that, for patients undergoing TKA, the addition of low-dose epidural morphine to single femoral nerve block and intravenous opioids can improve the postoperative analgesia, reduce the consumption of intravenous opioids and decrease opioid-associated side effects. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03203967
Study type	Interventional
Source	Peking University First Hospital
Contact
Status	Completed
Phase	N/A
Start date	July 1, 2017
Completion date	May 30, 2018

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See also
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Completed	`NCT03206554` - Local Infiltration Analgesia in Total Knee Arthroplasty	Phase 2
Completed	`NCT01616836` - Optimizing Pain and Rehabilitation After Knee Arthroplasty	Phase 3
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Not yet recruiting	`NCT00958945` - Retrospective Chart Analysis in the Effective Use of FloSeal in Post-Operative Joint Replacements	N/A
Completed	`NCT00985920` - Topical Tranexamic Acid for Total Knee Arthroplasty	Phase 4
Completed	`NCT00761956` - A Study to Compare the NexGen CR and CR-Flex Knee Implants	N/A
Completed	`NCT03289247` - Tissue Adhaesive in Wound Closure Following Primary Total Knee Arthroplasty	N/A
Terminated	`NCT03316118` - US Guided GNB vs Saline Injection for TKA	Phase 4
Recruiting	`NCT05962970` - Continuous Adductor Canal Block in Fast Track Total Knee Arthroplasty	N/A
Completed	`NCT03317834` - Navio With Total Knee Arthroplasty
Enrolling by invitation	`NCT06188091` - Joint Movement to Increase Range of Motion in Knee Joint After Primary Total Knee Arthroplasty	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Epidural Morphine for Postoperative Analgesia After Total Knee Arthroplasty

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms