Total Abdominal Hysterectomy Clinical Trial
Official title:
The Use of S Ketamine Versus Placebo During Target Controlled Intravenous Anaesthesia to Reduce Morphine Consumption and Side-Effects After Abdominal Hysterectomy: A Randomized Control Trial
This study investigates the effect of low dose S+ketamine compared to placebo on cumulative morphine consumption at 24 hours in women undergoing open abdominal hysterectomy with remifentanil-propofol target controlled infusion. It compares the adverse effect profile in patients receiving S+ketamine as compared to those who did not. Participants are randomly distributed in two groups of 45 patient's each.
In recent times it has been suggested that NMDA receptor antagonist like ketamine when used
in small doses helps reducing postoperative pain and opioid consumption without compromising
wakefulness and or causing its psycho mimetic adverse effect .
The clinical utility of S+ ketamine as an adjuvant intra-operatively remains controversial.
The NMDA receptor activation and subsequent biochemical process has been proven to play an
important role in both hyperalgesia after tissue injury and the development of opioid
tolerance. Various studies have reported the advantage of S+ ketamine over traditional
balanced anaesthesia, but may lead to secondary hyperalgesia and increased opioid
requirement in post operative period in both animals and healthy human volunteers. Other
studies showed that 48 hours continuous administration of small-dose ketamine, together with
patient-controlled analgesia (PCA) with morphine, or systemic, epidural co-administration of
ketamine and opiates markedly reduced cumulative morphine. However, the dosage, route and
timing of administration of S+-ketamine varied in different setting.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Not yet recruiting |
NCT00484835 -
Are Sutures Required in Total Abdominal Hysterectomy? A Randomised Control Trial
|
Phase 1 | |
| Recruiting |
NCT04285502 -
Comparison of Postoperative Drain Insertion Versus No Drain Insertion In Total Laparoscopic Hysterectomy
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N/A |