Tooth Erosion Clinical Trial
Official title:
A Randomized, Examiner Blind, Crossover, in Situ Erosion Study To Investigate The Efficacy Of An Experimental Dentifrice In Remineralization Of Softened Enamel Compared To Placebo and Reference Dentifrices
The purpose of this study is to investigate the ability of an experimental dentifrice containing 1150 parts per million (ppm) fluoride to remineralize acid-softened dental enamel and help prevent further demineralization compared to a 0 ppm fluoride placebo dentifrice and a marketed, fluoride-containing dentifrice (Reference Dentifrice).
This will be a randomized, controlled, single center, single-blind, 3 period, 3 treatment, cross-over, in situ design study. Previously demineralized bovine enamel specimens will be placed intra orally using a palatal appliance and the remineralizing performance of the experimental, reference and placebo dentifrices will be evaluated at 4 and 12 hours post toothbrushing, based on surface micro hardness measurements of the bovine enamel specimens. At each treatment visit, once the palatal the appliance is fitted in the mouth, a five minute equilibration period will ensue following which each participant will brush their teeth with their assigned product. Participants will remove the appliance for 30 minutes at 4 and 8.5 hours post brushing and will remove and store the appliance 13 hours post brushing (12 hours intraoral exposure). Sufficient participants will be screened to randomize approximately 33 participants to study treatment to ensure approximately 30 participants complete the study. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02548156 -
Intra Oral Kinetics of Fluoride Containing Dentifrices
|
N/A | |
| Completed |
NCT02533466 -
In Vivo Investigation of Initial Stages of Enamel Erosion
|
N/A | |
| Completed |
NCT04586322 -
Association Between Erosive Tooth Wear Progression and Dietary Risk Factors.
|
||
| Active, not recruiting |
NCT03112278 -
Clinical Evaluation of Ultrathin Occlusal Veneers for the Treatment of Severe Dental Erosion
|
N/A | |
| Completed |
NCT01622920 -
Preliminary Clinical Study of Ultrasound to Measure Enamel Thickness
|
Phase 1 | |
| Completed |
NCT00564330 -
In Vivo Quantification of Dental Demineralisation Using OCT With and Without Esomeprazole
|
Phase 1/Phase 2 | |
| Completed |
NCT03296072 -
In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste
|
Phase 3 | |
| Completed |
NCT03101943 -
Preventing Early Childhood Obesity, Part 1: Family Spirit Nurture, 3-9 Months
|
N/A | |
| Completed |
NCT03515902 -
The Effects of Mouthguard and Desensitizing Toothpaste in Reducing Dental Hypersensitivity
|
N/A | |
| Completed |
NCT02676219 -
Pilot Study Utilising an Impression Technique to Capture in Vivo Images of Teeth
|
N/A | |
| Completed |
NCT05146557 -
Associations Between Obesity, Dental Caries, Erosive Tooth Wear and Periodontal Disease in Adolescents: A Case Control-study
|
||
| Completed |
NCT03577834 -
The Effect of Vinegar Consumption on Visceral Fat and Blood Glucose Concentration
|
N/A | |
| Completed |
NCT01128972 -
Evaluation of a Test Mouthwash and Dentifrice Regimen in an In-situ Model of Dental Erosion
|
Phase 2 | |
| Completed |
NCT06136754 -
Investigate a Varnish to Protect From Erosive Toothwear
|
Phase 3 |