Tooth Erosion Clinical Trial
Official title:
In Vivo Quantification of Dental Demineralisation Using Optical Coherence Tomography Before and After Double-blind, Randomised Treatment With Esomeprazole or Placebo of Patients With Dental Erosions
Dental erosions in 30 male and female patients with proven abnormal gastrooesophageal reflux
will be assessed clinically and using a novel optical coherence tomography (OCT) laser
technique before and after double-blind randomization to antisecretory treatment with
esomeprazole 20mg or placebo bid for 3 weeks.
The primary objective is to quantify tooth substance loss as well as changes in optical
reflectance and scattering of dental hard tissues with and without acid inhibition.
Secondary objectives are:
To compare standardised visual scoring with OCT quantification of reflux damage at the
different time points on different teeth.
To assess sex differences in OCT- quantified dental tissue loss.
Dental erosions in 30 male and female patients with proven abnormal gastrooesophageal reflux
will be assessed clinically and using a novel optical coherence tomography (OCT) laser
technique before and after double-blind randomization to antisecretory treatment with
esomeprazole 20mg or placebo bid for 3 weeks.
The primary objective is to quantify tooth substance loss as well as changes in optical
reflectance and scattering of dental hard tissues with and without acid inhibition.
Secondary objectives are:
To compare standardised visual scoring with OCT quantification of reflux damage at the
different time points on different teeth.
To assess sex differences in OCT- quantified dental tissue loss
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Diagnostic
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