Tonsillitis Clinical Trial
The investigators wish to evaluate coblation channeling in the treatment of chronic tonsillitis.
The tonsillar crypts play an important role in chronic tonsillitis. They are covered by
stratified epithelium and may be initiated via the epithelium to mount immune responses to
various presenting antigens. Go M. et al, investigated the expression and function of tight
junctions in the epithelium of human palatine tonsils from patients with tonsillar
hypertrophy or recurrent tonsillitis. These studies suggested unique expression of tight
junctions in human palatine tonsillar epithelium, and it was suggested that the crypt
epithelium may possess an epithelial barrier different from that of the surface epithelium.
Bacteria within biofilms are resistant to host defenses and antibiotics. The presence of
bacterial biofilms within the tissue and crypts of inflamed tonsils may explain the
chronicity and recurrent characteristics of some forms of tonsillitis. There is strong
anatomical evidence for the presence of bacterial biofilms in chronically diseased tonsils.
Our hypothesis was that treatment of the crypts and tonsillar tissue may decrease the
possible antigen-immune system interaction and inflammation.
The combination of the radio frequency energy and the fluid creates a "plasma" field
containing highly ionized particles. The ionized particles have sufficient energy to break
organic molecular bonds that can remove tissue selectively without excessive heat production
and damage the surrounding tissue. Employing this new technique, the investigators will try
to eliminate the cause for chronic tonsillitis.
The combination of the radio frequency energy and the fluid creates a "plasma" field
containing highly ionized particles. The ionized particles have sufficient energy to break
organic molecular bonds that can remove tissue selectively without excessive heat production
and damage the surrounding tissue. Employing this new technique, the investigators will try
to eliminate the cause for chronic tonsillitis.
Our hypothesis was that treatment of the crypts and tonsillar tissue may decrease the
possible antigen-immune system interaction and inflammation.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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