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Tonsillitis clinical trials

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NCT ID: NCT06391151 Not yet recruiting - Pregnancy Clinical Trials

Effect of OSA Resulting From Chronic Tonsillitis on Pregnancy Outcomes

Start date: July 1, 2024
Phase:
Study type: Observational

This cohort study aims to investigate the impact of obstructive sleep apnea hypopnea syndrome (OSA) resulting from chronic tonsillitis on pregnancy outcomes. The hypothesis posits that chronic tonsillitis-induced OSA may exacerbate pregnancy complications and increase the risk of adverse pregnancy outcomes.

NCT ID: NCT04321733 Not yet recruiting - Clinical trials for Acute Follicular Tonsillitis

Bacteriological Study of Acute Follicular Tonsillitis

Start date: April 2020
Phase:
Study type: Observational

The objective of the study is to answer the following questions :- 1. Is there an actual failure rate in tonsillitis treatment with amoxicillin clavulanate ? If yes, 2. What is (are) the possible reason(s) to explain it in our locality ?

NCT ID: NCT04297878 Not yet recruiting - Sore Throat Clinical Trials

The BLIS Study: a Feasibility Study Assessing Compliance, Acceptability and Colonisation With Different Dosing Regimens of the Probiotic Supplement Streptococcus Salivarius K12 (Bactoblis®) in Adults

Start date: March 5, 2020
Phase: N/A
Study type: Interventional

Short title The BLIS study Full title A feasibility study assessing compliance, acceptability and colonisation with different dosing regimens of the probiotic supplement Streptococcus salivarius K12 (Bactoblis®) in adults Population 50 human adults with or without a history of significant sore throat in the past 12 months. We primarily aim to recruit participants with a history of sore throat, however we will also recruit healthy individuals if we are struggling to meet our recruitment target. Interventions Two groups will receive two different dosing regimens of Ssk12 probiotic oral lozenges: - Group A: two SsK12 lozenges at night on days 1, 7 and 14. - Group B: one SsK12 daily at night for 14 days. Throat swabs will be taken at baseline, and days 2, 7, 14, 21, 35 Objectives 1. To evaluate the prevalence of colonisation with SsK12 (as determined by real-time Polymerase Chain Reaction [PCR] and culture of participant-take whole-mouth swabs at pre-determined time points during the study) 2. To evaluate the acceptability of the two dosing regimens (as measured by participant-completed questionnaires) 3. To evaluate participants compliance with the two dosing regimens (as reported by participants during completion of the questionnaires) Rationale SsK12 probiotic supplements are recognised as safe food ingredients, and there is preliminary evidence to support their use as prophylactic therapy to prevent episodes of pharyngo-tonsillitis. Existing clinical trials have all given SsK12 once daily over a period of months. It remains unclear whether a once-daily dosing regimen is needed in order to establish and maintain colonisation. Study design This is a prospective study for which we will recruit healthy adult participants with and without a history of sore throat/ pharyngo-tonsillitis. We will evaluate [1] the acceptability and feasibility of two different dosing regimens of SsK12 supplements (taken as oral dissolvable lozenges), and [2] compare the prevalence of colonisation with SsK12 at various time points in order to determine how long colonisation is maintained following a loading dose. A baseline whole-mouth swab will be taken, and participants will be randomly assigned (in a 1:1 ratio) to one of two groups ('A' or 'B'). Group A will take two SsK12 lozenges at night on days 1, 7 and 14. Group B will take SsK12 at night for 14 days. Participants will be provided with instruction on how to perform a self-taken whole-mouth swab, and asked to take swabs on days 2, 7, 14, 21, and 35, and return these to the study team by post. They will also be asked to complete two short online questionnaires (on day 14 and day 35) about their compliance with the probiotic, as well as their views on the dosing regimen and other aspects of the study. Maintenance of colonisation will be assessed using analysis of the returned throat swabs. No follow-up will be undertaken after day 35. Sample size Total = 50 (25 in group A, and 25 in group B) Setting 1. NIHR Clinical Research Facility, Southampton General Hospital 2. Cowley Road Medical Practice, Oxford

NCT ID: NCT03704506 Not yet recruiting - Acute Tonsillitis Clinical Trials

Registration of the Study of Reyanning Mixture

Start date: October 22, 2018
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the efficacy and safety of treating with acute tonsillitis using Reyanning mixture alone/in combination with antibiotics, and its function of reducing the use of antibiotics.

NCT ID: NCT02981810 Not yet recruiting - Chronic Tonsillitis Clinical Trials

Evaluation of Coblation Channeling Treatment for Chronic Tonsillitis.

Start date: December 2016
Phase: N/A
Study type: Interventional

To evaluate coblation channeling treatment for chronic tonsillitis. Does Tonsillar ablation can create changing in the tonsillar medium for recurrent tonsillar infections and stop the recurrent infections?

NCT ID: NCT02972437 Not yet recruiting - Tonsillitis Clinical Trials

Detection of Group A Streptococcus (GAS) in Oral Cavity

Start date: December 2016
Phase: N/A
Study type: Observational

The investigators intend to screen children who are suspected of having GAS tonsillitis. From each child we will take a throat culture and saliva sample to screen for molecular evidence of GAS.

NCT ID: NCT02848287 Not yet recruiting - Tonsillitis Clinical Trials

Influence of 0.75% Ropivacaine Topicalization on Emergence Agitation in Children

Start date: August 2016
Phase: N/A
Study type: Interventional

Emergence agitation (EA) is highly prevalent in children after surgery. Risk factors for EA are Eye, nose and throat (ENT) surgery, preoperative anxiety, postoperative pain. There are several preventive strategies but none of them completely prevent EA. Topical application of ropivacaine can reduce post-tonsillectomy pain. Therefore, it might reduce the incidence of postoperative EA.

NCT ID: NCT02715037 Not yet recruiting - Clinical trials for Infectious Mononucleosis

Microbiology of Severe Acute Tonsillitis, Peritonsillar Cellulitis, and Infectious Mononucleosis

Start date: June 2016
Phase: N/A
Study type: Observational

Prospective, observational study of the microbiology of patients referred to a tertiary care center with severe acute tonsillitis, peritonsillar cellulitis, or infectious mononucleosis.

NCT ID: NCT01193790 Not yet recruiting - Tonsillitis Clinical Trials

Evaluation of Coblation Channeling in Treating Chronic Tonsillitis

Start date: January 2011
Phase: Phase 2
Study type: Interventional

The investigators wish to evaluate coblation channeling in the treatment of chronic tonsillitis.

NCT ID: NCT00466544 Not yet recruiting - Tonsillitis Clinical Trials

Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy

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Start date: May 2007
Phase: Phase 4
Study type: Interventional

Study objective is to provide prospective randomized controlled data on pediatric pain levels found in PlasmaKnife tonsillectomy and monopolar tonsillectomy.