Tonsillar Abscess Clinical Trial
Official title:
Treatment of Tonsillar Abscess: A Randomized Clinical Trial in a Tertiary Center
The diagnosis and treatment of tonsillar abscess are very physician-dependent, as sufficient prospective medical literature is lacking to choose the most efficient regimen. The proposed study aims to assess the therapeutic efficacy of tonsillectomy compared to drainage under local anesthesia. This is a prospective, randomized clinical trial in adults in a tertiary care center in Geneva (Switzerland).
Status | Recruiting |
Enrollment | 150 |
Est. completion date | May 31, 2024 |
Est. primary completion date | December 31, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients =18 years of age with clinical suspicion of unilateral tonsillar abscess without signs of "extra-capsular" complication. - Obtaining informed consent. Exclusion Criteria: - Contraindications to injected CT or drainage in local anesthesia (allergy to iodinated contrast product, allergy to local anesthetics, phobia of needles, major trismus). - Parapharyngeal or retropharyngeal abscess, or associated venous thrombosis found on CT. - Imminent threat to the upper respiratory tract (glottic edema, acute dyspnea). - Inability to understand the different procedures (dementia, impossible communication, substance abuse). - Anamnestic pregnancy. - Antiaggregant or anticoagulant treatment. - Treatment of corticosteroids during the management of emergencies and in hospital. |
Country | Name | City | State |
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Switzerland | University Hospitalas Geneva | Geneva |
Lead Sponsor | Collaborator |
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University Hospital, Geneva |
Switzerland,
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* Note: There are 18 references in all — Click here to view all references
Type | Measure | Description | Time frame | Safety issue |
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Primary | Proportion of treatment success (%) | Disappearance of fever if any + decrease in leukocytosis and CRP value + no sign of recollection nor cervical extension of the infection. | 3 days | |
Secondary | Recurrence rate (%) | Reccurence of a tonsillar abscess on the same side post-operatively. | 3 and 12 months |