Tolerance Clinical Trial
Official title:
Tolerance and Utilization of Polydextrose, Inulin, and Soluble Corn Fiber
The objective of this study is to determine the tolerance and utilization of polydextrose and soluble corn fiber through analyses of fecal samples of fermentative end-products (short-chain fatty acids, ammonia, phenol, and indole) and shifts in microbial populations.
Soluble fibers have been shown to have many positive effects in humans, including laxation
and maintaining gastrointestinal health. It is expected that feeding soluble fibers will
decrease protein fermentative end=products while increasing carbohydrate fermenative
end-products, and lead to a more beneficial microbial profile. Determination of the effects
of nutriose and polydextrose when included as supplemental fiber in a human diet will give
insights to its potential to maintain or improve gut health and highlight its use in the
food industry.
The object of this study are first to determine the tolerance of soluble fibers
polydextrose, inulin and nutriose when provided as supplemental fiber to an existing diet.
The second objective is to determine the utilization of polydextrose and nutriose through
analyses of fecal samples of fermentative end-products and shifts in microbial populations.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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