Cigarette Harm Reduction With Electronic Cigarette Use — NIDA-SREC  

Nicotine Dependence Clinical Trial

Official title: Cigarette Harm Reduction With Electronic Cigarette Use

Status Withdrawn

Clinical Trial Summary

This is an observational, crossover study that will be examine use behaviors, chemical exposures, and biological effects of SREC compared to TC use in subjects confined to a research ward setting.

Clinical Trial Description

Daily cigarette smokers who are familiar with e-cigarette (EC) use will be instructed to use only NIDA Standardized Research Electronic Cigarettes (SREC) and tobacco cigarettes (TC) while enrolled on the study. Our overall goals are two-fold: (1) to compare nicotine and toxicant exposure and pharmacological effects of SREC used alone vs tobacco cigarettes alone (TC), or dual use; and (2) using SREC alone, TC alone, or ad libitum SREC use combined with 50% reduction in usual TC use as a model for dual use, to examine the extent to which nicotine and toxicant exposure and biomarkers of potential harm compare among the 3 groups. The former would inform the effects of total switching, the latter would inform the potential harm reducing effects of smoking fewer TC while using EC. ;

Related Conditions & MeSH terms

• Cardiovascular Risk Factor
• Nicotine Dependence
• Nicotine Dependence, Cigarettes
• Nicotine Withdrawal
• Tobacco Toxicity
• Tobacco Use Disorder

• NCT number: NCT03473483
• Study type: Interventional
• Source: University of California, San Francisco
• Status: Withdrawn
• Phase: N/A
• Start date: August 1, 2022
• Completion date: March 31, 2026