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Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

Tobacco Dependence Clinical Trial

Official title:
Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes

Clinical Trial Summary

The overall goal of this study is to determine if switching to very low nicotine content cigarettes changes the function of brain circuitry involved in incentive salience and executive control among dependent smokers.

Clinical Trial Description

In a double-blind, randomized controlled trial, dependent smokers will be randomized to a 6-week very low nicotine content (VLNC) cigarette condition (N=50) or a 6-week normal nicotine content cigarette control condition (NNC; N=25). Participants will undergo functional magnetic resonance imaging (fMRI) scans at baseline and 6-weeks to investigate the nicotine-related modulation of brain circuitry involved in incentive salience valuation and executive control. Imaging tasks will engage the incentive salience of smoking cues and non-smoking rewards and executive control functions to identify changes in functional activity within, and effective connectivity between, known salience and executive control brain circuitry. A novel fMRI task using specialized odor presentation equipment and fMRI sequences will assess neural cue reactivity to smoke odors. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03612960
Study type Interventional
Source Milton S. Hershey Medical Center
Contact
Status Active, not recruiting
Phase N/A
Start date February 20, 2020
Completion date January 2024
View Details
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