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Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1

Tobacco Dependence Clinical Trial

Official title:
Targeted Pharmacological and Behavioral Treatments for Smoking in Schizophrenia Study 1

Clinical Trial Summary

Schizophrenia is associated with high rates of cigarette smoking and associated morbidity and mortality. In this study, smokers with schizophrenia will complete a baseline session and then randomized to varenicline (VAR) or placebo (PLA). After 1 week on medication, participants will complete a cigarette rating task session. Participants will then undergo a 72-hr abstinence period in which they will come to the laboratory twice per day and receive high-value cash reinforcement contingent upon meeting a strict breath CO abstinence criterion. At each visit, they will rate withdrawal symptoms, mood and craving. At the end of the abstinence period, they will repeat the cigarette rating task. Participants will return to the lab to provide a CO sample 24 hours later, and will text the lab with videos of their CO samples for one week. Date and time of smoking relapse will be measured from these samples.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03507127
Study type Interventional
Source Brown University
Contact
Status Terminated
Phase Phase 2
Start date May 1, 2018
Completion date June 30, 2019
View Details
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