Tinnitus, Subjective Clinical Trial
Official title:
Cohort Study on Biomarkers and Clinical Treatment of Tinnitus
The goal of this clinical trial is to search for biomarkers in tinnitus patients in tinnitus patients and changes in biomarkers before and after treatment. The main questions it aims to answer are: - What are the biomarkers of tinnitus patients? - How do these biomarkers change during treatment and is there a good correlation with behavioral outcomes? Participants will be asked to complete audiological examination, tinnitus assessment, and magnetoencephalography examination, and they will receive sound therapy or repetitive transcranial magnetic stimulation therapy.
Status | Recruiting |
Enrollment | 40 |
Est. completion date | December 2024 |
Est. primary completion date | December 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | N/A to 65 Years |
Eligibility | Inclusion Criteria: 1. Subjective tinnitus lasting for more than 6 months, with a score of>36 of the Tinnitus Disability Inventory (THI); 2. The otoscopy examination showed that the ear canal and eardrum were normal, and the tympanic impedance maps of both ears were Type A, indicating that language ability met the requirements of language testing Exclusion Criteria: 1. Family or congenital deafness history, ototoxicity drug use history, otitis media patients, etc 2. Suffering from major physical diseases (sensory and motor disorders, neurological disorders, brain injuries, and other organic diseases) or mental disorders 3. The patient has aggressive behavior and an impulse to damage the device 4. Metal in the body (including orthodontics, dental implants), tattoos, and heart stent surgery 5. Having claustrophobia 6. Contraindications to magnetic resonance examination |
Country | Name | City | State |
---|---|---|---|
China | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Shanghai | Shanghai |
Lead Sponsor | Collaborator |
---|---|
Zhiwu Huang, Ph.D. |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | THI | the scores of tinnitus handicap inventory(0-100) | Baseline | |
Primary | THI | the scores of tinnitus handicap inventory(0-100) | within 7 days of treatment completion | |
Primary | THI | the scores of tinnitus handicap inventory(0-100) | follow-up for 1 month after treatment completion | |
Primary | VAS | Visual Analog Scale (VAS) is used to evaluate the loudness of tinnitus. The score range is 0-10 | Baseline | |
Primary | VAS | Visual Analog Scale (VAS) is used to evaluate the loudness of tinnitus. The score range is 0-10 | within 7 days of treatment completion | |
Primary | VAS | Visual Analog Scale (VAS) is used to evaluate the loudness of tinnitus. The score range is 0-10 | follow-up for 1 month after treatment completion |
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