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Tick-borne Encephalitis and Positive Borrelial Antibodies — TBE-LB2014  

Tick-borne Encephalitis Clinical Trial

Official title:
Management of Patients With Tick-borne Encephalitis and Positive Anti-Lyme Borreliae Antibody Results

Clinical Trial Summary

In Slovenia, tick-borne encephalitis and Lyme borreliosis are both endemic diseases with high incidence rates and they are both transmitted by a bite of infected Ixodes ricinus tick. In clinical practice, tick-borne encephalitis is confirmed by demonstration of tick-borne encephalitis antibodies in serum of a patient with compatible clinical presentation and cerebrospinal pleocytosis. Patients with Lyme meningitis or meningoradiculitis also have cerebrospinal pleocytosis, however the presence of borrelial antibodies in serum does not attest Lyme neuroborreliosis.

Patients with tick-borne encephalitis and positive borrelial antibodies in serum, but not fulfilling criteria for Lyme neuroborreliosis, are often being treated with antibiotics in several European countries due to the possibility of double infection. The investigators hypothesise that such patients do not benefit from antibiotics. Such an approach may appear safe regarding the possibility of borrelial infection, however it can also be associated with detrimental consequences such as antibiotic related adverse reactions, negative epidemiological impact on bacterial resistance, and intravenous catheter related complications.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02463942
Study type Interventional
Source University Medical Centre Ljubljana
Contact Daša Stupica, MD, PhD
Phone +386 1 5222110
Email dasa.stupica@kclj.si
Status Recruiting
Phase N/A
Start date September 2014
Completion date September 2020
View Details
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