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Tic Disorders clinical trials

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NCT ID: NCT02864589 Completed - Tourette's Disorder Clinical Trials

Internet-based Behaviour Therapy for Tourette's Disorder and Chronic Tic Disorder

Start date: August 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the feasibility and acceptability of two different modalities of therapist-guided Internet-delivered behaviour therapy (IBT) for children and adolescents (7-17 years) with Tourette's Disorder (TD) or Persistent (Chronic) Motor or Vocal Tic Disorder (PTD).

NCT ID: NCT02676492 Completed - Tic Disorders Clinical Trials

A Naturalistic Study Investigating Sleep and Cognitive Learning in Children With and Without Tic Disorders

Start date: March 2016
Phase: N/A
Study type: Observational

This study will explore the relationship between sleep, learning, cognition, mood and behaviour in children with Tic Disorders (Tourette Syndrome and Chronic Tic Disorder) compared to typically developing peers.

NCT ID: NCT02605902 Completed - Tourette Syndrome Clinical Trials

Trial to Demonstrate the Efficacy and Safety of Internet-delivered Behavioral Treatment for Adults With Tic Disorders

ONLINE-TICS
Start date: September 29, 2016
Phase: N/A
Study type: Interventional

Gilles da la Tourette syndrome (TS)* is a common chronic neuropsychiatric disorder characterized by motor and vocal tics. In most adult patients, quality of life is significantly impaired. TS, therefore, is a cost-intensive disease (in Germany: mean total costs=€3404/year). Despite significant adverse effects, dopamine receptor antagonists were recommended as first choice treatment for many years. Although efficacy could be demonstrated only recently, today, behavioral therapy with face-to-face Comprehensive Behavioral Intervention for Tics (CBIT) (including psychoeducation, habit reversal training, function-based assessment and intervention, and relaxation training) is recommended as first line treatment for tics. In Germany, however, dissemination of CBIT is restricted due to a considerable lack of well-trained therapists. The aim of this study is to overcome this deficiency by creating a new and sophisticated internet-delivered CBIT (iCBIT) program. In addition, internet-delivered CBIT will shorten waiting time, will reach additional groups of patients and will be - once developed and established - highly cost-effective (about € 100 vs. € 1450 for face-to-face CBIT). Investigators want to perform a multicenter, randomized, controlled, observer-blind trial including 160 adult patients in order to demonstrate that 8 sessions (10 weeks) of iCBIT are superior to internet-delivered psychoeducation/relaxation in adult patients with TS. Both immediate (1 week after end of treatment) and long-term effects (after 3 and 6 months) will be evaluated.

NCT ID: NCT02582515 Completed - Clinical trials for Chronic Tic Disorder

Augmentation of Brief Habit Reversal Training With D-cycloserine or Placebo

DCS+HRT
Start date: October 2015
Phase: N/A
Study type: Interventional

Expert reviews and practice parameter papers recommend behavior therapy as a first-line intervention for youth with chronic tic disorders (CTDs) with mild-to-moderate tic severity. Although behavior therapies like the Comprehensive Behavioral Intervention for Tics (CBIT) are efficacious in reducing tic symptom severity, only 50% of individuals exhibit a positive treatment response. Thus, there is a clear need to identify strategies to improve treatment response and/or accelerate therapeutic gains . The primary ingredient of CBIT is habit reversal training (HRT), which utilizes both extinction and associative learning. Psychosocial treatments relying on these learning mechanisms have demonstrated an enhanced and/or expedited therapeutic benefit when augmented with d-cycloserine (DCS). This feasibility study will examine the incremental efficacy of HRT+DCS over HRT+placebo for tics targeted with HRT. Eligibility criteria will parallel the child CBIT trial for generalizability and comparability, with the addition of DCS contraindications as exclusionary criteria. Parents and youth will complete a battery of clinical assessments to ascertain tic symptoms severity and co-occurring psychiatric conditions. Afterwards, participants will be randomly assigned to receive either HRT+DCS or HRT+placebo. Instead of a full course of HRT (8 sessions over 10 weeks), a more efficient Quick-Win/Fast-Fail trial design will be used that includes a truncated HRT protocol to provide results in a more timely fashion. As a result of this trial design, the primary outcome of this study will focus on the reduction of bothersome tic severity for those targeted in treatment rather than global severity reductions.

NCT ID: NCT02413216 Completed - Tourette's Disorder Clinical Trials

TicHelper: A Computerized Comprehensive Behavioral Intervention for Tics (CBIT)

Start date: August 2015
Phase: N/A
Study type: Interventional

Tic Disorders (including Tourette Disorder) are relatively common in school-age children and for some children can lead to significant psychosocial and physical impairment and diminished quality of life. Non-pharmacological treatments have been shown to be effective for reducing tics in some children. These treatment options are desired by parents, but are not widely available. The investigators recently developed an online, computerized, self-administered version of CBIT called TicHelper.com. The current study will test the efficacy of TicHelper.com in a randomized clinical trial.

NCT ID: NCT02407951 Not yet recruiting - Tourette Syndrome Clinical Trials

Group Intervention for Children With Chronic Tics Syndrome or Tourette Syndrome: CBIT vs Psycho-Educational Intervention

Start date: April 2015
Phase: N/A
Study type: Interventional

Tourette Syndrome (TS) is a disorder characterized by motor and vocal tics. The most studied and promising intervention is Habit Reversal Training (HRT) and its variations: Behavioral Comprehensive Intervention for Tics (CBIT). Group intervention for children with TS has not been evaluated. The aim of this study is to assess the efficacy of CBIT group intervention compared with Psycho-Educational-Supportive group in terms of tic severity.

NCT ID: NCT02247206 Completed - Tourette Syndrome Clinical Trials

VoIP Delivered Behavior Therapy for Tourette Syndrome

Start date: December 2012
Phase: Phase 2
Study type: Interventional

The purpose of this research is to examine the preliminary efficacy, feasibility, and acceptability of Voice over Internet Protocol delivered behavior therapy for Tourette Syndrome through in a randomized waitlist-controlled trial.

NCT ID: NCT02205918 Completed - Tourette's Syndrome Clinical Trials

Brain-Behavior Interactions in Tic Suppression

Start date: July 1, 2017
Phase:
Study type: Observational

The purpose of this study is to examine how the brain and environment interact to influence children's ability to suppress tics using a medical technology called Transcranial Magnetic Stimulation (TMS).

NCT ID: NCT02190383 Recruiting - Tic-Disorder Clinical Trials

Efficacy of a Habit Reversal Treatment on Tic-symptoms

Start date: November 2013
Phase: N/A
Study type: Interventional

The main purpose of this study is to evaluate the efficacy of a habit reversal based treatment programme in children and adolescents aged 8 to 18 years with tic disorders.

NCT ID: NCT02190370 Recruiting - Tic-Disorder Clinical Trials

Efficacy of a Resources Activation Treatment on Tic-symptoms

Start date: November 2013
Phase: N/A
Study type: Interventional

The main purpose of this study is to evaluate the efficacy of a resources activation based treatment programme in children and adolescents aged 8 to 18 years with tic disorders.