Therapeutic Plasma Exchange in Thyrotoxicosis

Thyrotoxicosis Clinical Trial

Official title:

Preoperative Therapeutic Plasma Exchange and Surgical Treatment in Thyrotoxicosis Patients: a Single-centre Retrospective Cohort Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04485975
• Other study ID #: KA20/244
• Status: Completed
• Start date: January 1, 1999
• Est. completion date: April 1, 2020

Study information

• Verified date: July 2020
• Source: Baskent University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.

Description:

Background: Therapeutic plasma exchange (TPE) is indicated in cases where antithyroid medications cannot be used due to the side effects or attain no adequate hormonal suppression response at the highest dosage and in cases of rapid onset of clinical symptoms. This study presents the treatment results of patients who underwent TPE and subsequently operated for thyrotoxicosis.

Methods: The files of 27 patients who underwent preoperative TPE for thyrotoxicosis between January 1999 and February 2019 were retrospectively analyzed. The demographic and clinical features of the patients were included.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 27
• Est. completion date: April 1, 2020
• Est. primary completion date: February 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• thyrotoxicosis unresponsive to medication

• adverse reaction to the medications

• need for rapid treatment in patients that need urgent surgery

Exclusion Criteria:

• The patients who did not undergo surgery post-therapeutic plasma exchange

• Preoperative hypocalcemia,

• hemodynamically unstable patients

• patients not suitable for central catheter placement

Related Conditions & MeSH terms

• Thyrotoxicosis

Intervention

Device:
• Therapeutic plasma exchange
Therapeutic plasma exchange filtrates plasma and decreases thyroid hormone concentration in the blood

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Baskent University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Thyroid hormone levels of patients after therapeutic plasma exchange	Concentration of serum thyroid hormone levels before thyroidectomy	1 week before the operation