Genetic Analysis of Thyrotoxic Periodic Paralysis

Thyrotoxic Periodic Paralysis Clinical Trial

Official title:

Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00443833
• Other study ID #: 11-46-21
• Status: Completed
• Phase: N/A
• First received: March 5, 2007
• Last updated: March 5, 2007
• Start date: January 2004
• Est. completion date: December 2005

Study information

• Verified date: March 2007
• Source: Ramathibodi Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Thailand: Ethical Committee
• Study type: Observational

Clinical Trial Summary

Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Description:

This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 80
• Est. completion date: December 2005
• Accepts healthy volunteers: No
• Gender: Male
• Age group: 15 Years and older

Eligibility

Inclusion Criteria:

TPP

• Hyperthyroid patients from any causes

• Evidence of hypokalemia (k<3.5 mg/dl)from intracellular shift (Urine K<15 mg/dl, TTKG<2)

• Episodic paralysis

Exclusion Criteria:

• Hypokalemia from GI or renal loss

Study Design

Observational Model: Case Control, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Paralysis
• Thyrotoxic Periodic Paralysis

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ramathibodi Hospital