Clinical Trials Logo

Clinical Trial Summary

The aim of the study is to evaluate the effectiveness of autofluorescence in the intraoperative preservation of parathyroids during total thyroidectomy


Clinical Trial Description

Real-time intraoperative identification and functional maintenance of structures are of major importance in endocrine surgery, with a critical role in clinical outcomes and patients' quality of life. Despite the advances in preoperative imaging techniques, there is still need for precise intraoperative visualizing. Limitations of naked eye inspection and subjectivity of palpation are imposing challenges even for the most experienced surgeons. Nowadays, attention is attracted to intraoperative imaging techniques using Near Infrared Fluorescence (NIRF) with endogenous or exogenous contrast agents. These imaging techniques are attractive in biomedicine due to its high penetration depth and low scattering in human tissue.

Autofluorescence is the ability of several natural substances or drugs to be fluorescent after the absorbance of light or radiation. It has been already proved that parathyroid glands emit their own light after near-infrared (NIR) around 820nm , providing high contrast to the surrounding tissues. This made near-infrared autofluorescence a potential useful tool in hands of experienced endocrine surgeons in order to distinguish parathyroid glands from other anatomic structures during thyroidectomies.

Approximately 7.6% of thyroid surgeries resulted in hypoparathyroidism, with 75% of these cases being transient and 25% being chronic. The mechanisms that underlie hypoPTH are related to disruption of parathyroid arterial supply or venous drainage, mechanical injury, thermal or electrical injury, and either intentional or inadvertent partial or complete removal.

The aim of the present study is to evaluate the value of intra-operative autofluorescence imaging concerning the unintentional excision rate of parathyroids during total thyroidectomy. Moreover, the investigators are going to evaluate correlation of autofluorescence with 24 hours post-operative PTH. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04204317
Study type Observational
Source Aristotle University Of Thessaloniki
Contact
Status Completed
Phase
Start date December 17, 2019
Completion date March 27, 2020

See also
  Status Clinical Trial Phase
Completed NCT02855866 - Interest of Cryotherapy or Cortisone Aerosol Therapy in Early Post-operative Swallowing Disorders Following Total Thyroidectomy N/A
Completed NCT05044351 - Autofluorescence-guided Hemithyroidectomy in a Low-volume, Non-parathyroid Insitution: A Randomized Clinical Trial N/A
Completed NCT05043584 - Near-infrared Autofluorescence (NIRAF)-Guided Total Thyroidectomy: Impact in Low-volume, Non-parathyroid Institutions N/A
Completed NCT04082845 - Effect of Web-Based Training With Thyroidectomy Patients N/A
Completed NCT04186715 - Near Infrared Spectroscopy in Thyroidectomy
Not yet recruiting NCT02949856 - E-T Tube Cuff Pressure Change After Changing Position From Neutral to Hyperextension of Neck N/A
Completed NCT02136459 - Non-neural Vocal Changes After Thyroidectomy N/A
Withdrawn NCT03060499 - Post Thyroidectomy Myocardial Function
Completed NCT03108742 - Randomized Control Study of Dermal Staples vs Subcuticular Sutures on Postoperative Scar After Thyroidectomy N/A
Completed NCT03035383 - Purse String Suture for the Closure of Large Thyroidectomy Resulted in Better Cosmetics N/A
Recruiting NCT06002984 - Effectiveness of Intraoperative Neuromonitoring of External Branch of Superior Laryngeal Nerve in Thyroid Surgery N/A
Recruiting NCT06162390 - Optimal Concentration of Remifentanil for NIM Tube Intubation With Low-dose NMBA N/A
Recruiting NCT04481893 - Interest of the Virtual Reality Headset in the Management of Perioperative Stress in Patients Candidates for Total Thyroidectomy N/A
Completed NCT02577068 - Combination Effect of Nefopam With Propacetamol for Postoperative Pain After Thyroidectomy N/A
Completed NCT03349294 - Clinical Study of Biokinetic Model of Iodine-131 in Total(Near) Thyroidectomy Patients.
Recruiting NCT05851560 - Prospective Comparison of the Effect on Antiadhesive Barriers During Thyroid or Parathyroid Surgery Phase 1
Completed NCT02768753 - Comparison Between the Axillary Bilateral-breast Approach (ABBA) and Bilateral Axillo-breast Approach (BABA) for Robotic Thyroidectomy N/A
Recruiting NCT05642741 - Validation of a Hypoparathyroidism Self-questionnaire
Withdrawn NCT02568085 - Trial Evaluating Use of Arista in Total Thyroidectomy N/A
Recruiting NCT01607242 - Impact of Total Thyroidectomy on Voice and Swallowing N/A