Thyroidectomy Clinical Trial
Official title:
Phase 1 Study of Electrical Impedance Spectroscopy in Thyroid and Parathyroid Surgery
NCT number | NCT02901873 |
Other study ID # | STH18736 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | June 27, 2016 |
Est. completion date | June 27, 2017 |
Verified date | September 2018 |
Source | Sheffield Teaching Hospitals NHS Foundation Trust |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Parathyroid glands are involved in calcium metabolism and their damage during neck surgery
results in 'hypoparathyroidism', a condition characterized by 'low blood calcium' levels;
this is associated with significant short and long term morbidity. There are four parathyroid
glands in the neck which can vary in size and location. They can be mistaken for lymph nodes,
fat or thyroid nodules. A normal parathyroid gland is the size of a small pea and is often
difficult to recognize during surgery; making it susceptible to inadvertent injury or
removal.
Thyroid and parathyroid surgery are commonly performed in the UK. Prompt and accurate
identification of parathyroid tissue during surgery reduces the likelihood of
hypoparathyroidism. However, this complication is still common. Research exploring the use of
intraoperative technologies to enable early identification and preservation of normal
parathyroid glands during surgery is ongoing. Electrical impedance spectroscopy (EIS) is one
such technology. ZedScanTM is a handheld device that measures electrical impedance of
tissues. It is currently used as a adjunct during colposcopy in cervical cancer screening.
The device has a CE mark for this purpose and is safe to use in humans. We have already
demonstrated that electrical impedance spectroscopy can detect differences in cellular
structure and differentiate between tissues in the rabbit neck. We now aim to demonstrate the
feasibility of using this technology (ZedScanTM) in humans. This has potential to be used in
thyroid and parathyroid surgery to differentiate parathyroid glands from other structures;
thereby decreasing their damage and the risk of post surgical hypothyroidism.
Status | Completed |
Enrollment | 56 |
Est. completion date | June 27, 2017 |
Est. primary completion date | June 27, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - All adult patients (18 years and over) undergoing thyroid and/or parathyroid surgery in Sheffield Teaching Hospitals NHS Foundation Trust (STH) will be eligible for inclusion in this study. Exclusion Criteria: - - Patients undergoing thyroglossal cyst surgery, re-do procedures only involving resection of lymph nodes - Patients unable to understand spoken and written English - Patients unable to give adequate informed consent - Patients with a positive pre-operative pregnancy test |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Royal Hallamshire Hospital | Sheffield | South Yorkshire |
Lead Sponsor | Collaborator |
---|---|
Sheffield Teaching Hospitals NHS Foundation Trust |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | generation of electrical impedance spectral curves (EI across the range of frequencies) for thyroid, parathyroid, muscle, lymph nodes and adipose tissues | single surgery |
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