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Thyroid Nodule clinical trials

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NCT ID: NCT03547648 Completed - Thyroid Nodule Clinical Trials

Effect of Three Different Peak Airway Pressures on Determining Intraoperative Bleeding in Thryroidectomies

Start date: June 15, 2018
Phase: N/A
Study type: Interventional

Patients undergoing thyroidectomy will be divided into three groups (30 cm H2O Group I, 40 cm H2O Group II, 50 cmH2O Group III). At the end of the operation patients will be applied peak airway pressure manually according to involved groups.The time until the first hemorrhage is seen in each group or if not seen pressure will be applied for 30 seconds and then will be ended.We will record the blood pressure, spO2, HR, the first ETCO2 after the procedure, postoperative haemorrhage that required surgery, and postoperative hematomas during peak airway pressure increase during the operation in all patients. The 1st hour blood pressure, nausea-vomiting score and pain score (NRS) will be recorded in the postoperative recovery unit. The primary end point of the study is intraoperative bleeding detected, and the secondary end point is postoperative bleeding.

NCT ID: NCT03535974 Completed - Clinical trials for Benign Thyroid Nodule

Efficacy of a Spirulina Supplement for Amelioration of Benign ThYroid Nodules

ESSAY
Start date: May 15, 2018
Phase: N/A
Study type: Interventional

Clinical trial with a double-blind, placebo-controlled, crossover design; enrolls approximately 30 euthyroid patients with benign thyroid nodules, who will receive for 6 weeks a spirulina-based supplement, and for another 6 weeks placebo. Thyroid ecography will be performed three times for each patient, and blood tests including TSH, free T4, free T3 and ceruloplasmin/Copper will also be performed 3 times for each patient. It is expected that a decrease in the thyroid nodules occurs with the supplement administration. Compared with placebo there will be a decrease of at least 20% in the volume or the largest diameter of the nodules during the 6-week administration of the supplement.

NCT ID: NCT03469310 Completed - Thyroid Cancer Clinical Trials

Minimizing Narcotic Analgesics After Endocrine Surgery

Start date: March 9, 2018
Phase: Phase 4
Study type: Interventional

This research is being done to better understand and test if the investigators can minimize narcotic medication for controlling pain after thyroid or parathyroid surgery. This research will be performed at Doctors Hospital At Renaissance in the investigators clinic and the perioperative area. Participants will be randomly chosen to receive one of two options for pain management that the investigators are already using in the care of patients after surgery. One option includes a narcotic medication and one option includes a non-narcotic and a narcotic as needed. Participants will be asked to complete a form about the level of pain and how much pain medication was needed after surgery in the hospital and while at home. Participants will not have to do any additional visits to participate in this study. The investigators will obtain the research materials at the same time as the usual care visits around the participants' surgery.

NCT ID: NCT03392402 Completed - Thyroid Cancer Clinical Trials

Molecular Classifier for the Fine Needle-based Assessment of Malignancy Risk in Thyroid Nodules

ThyroPred-1
Start date: January 1, 2017
Phase:
Study type: Observational

This study evaluates the usefulness of molecular classifier to aid the diagnosis of malignancy in the material obtained by fine-needle aspiration biopsy (FNAB) of thyroid nodule. All participants will undergo FNAB with routine cytological assessment and molecular testing. Patients will undergo surgery or be followed-up, according to the clinical guidelines. The diagnostic power of combined molecular/clinical classifier will be compared to prediction based on clinical features only, by investigators blinded to the final diagnosis of surgical assessment.

NCT ID: NCT03331172 Completed - Thyroid Nodule Clinical Trials

HIFU Reapplication in Benign Nodules

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

High Intensity Focused Ultrasound (HIFU) is a new approach in treating benign thyroid nodule without surgery. It is proven effective and safe relative to traditional surgery. From previous HIFU studies, it caused shrinkage of thyroid nodule up to 70% from original size. Unfortunately, 5-10% of nodule do not shrink. Those which do not shrink are usually large in size and therefore a second HIFU treatment may help. This study is going to evaluate the efficacy and safety of reapplication HIFU after the first single HIFU session in 6 months. The study will be carried out in the following steps: 1. Recruit subject from the clinic according to the study criteria. 2. Arrange the reapplication HIFU treatment within 3 months. 3. Arrange 4 visits after the HIFU treatment in Post 7 days, Post 1 month, Post 3 months, and Post 6 months; Data collection will be in these 4 visits through the questionnaire or interview by research assistant 4. The subjects will have further health management with the same team after the study.

NCT ID: NCT03307694 Completed - Cancer, Thyroid Clinical Trials

Thyroid Ultrasound Elasticity (TrUE) Imaging

Start date: October 23, 2017
Phase:
Study type: Observational

In this study the researchers will scan the thyroid nodules of patients scheduled for surgical removal of these nodules. During their preadmission testing, but prior to their surgery, the researchers will perform standard ultrasound and shear wave elasticity imaging (SWEI) scans of the thyroid nodules in these patients. Both images can be generated by the same ultrasound scanner and within the same imaging session without having to switch out any equipment. The results of the SWEI scans will be compared to the definitive diagnosis from pathology obtained after pathologists have examined the removed nodules post-operatively.

NCT ID: NCT03257930 Completed - Thyroid Nodule Clinical Trials

Percutaneous Ethanol Injection for Benign Cystic Thyroid Nodules

Start date: August 11, 2017
Phase: Phase 1
Study type: Interventional

Use of ethanol injection in treatment of cystic thyroid nodule

NCT ID: NCT03183752 Completed - Insulin Resistance Clinical Trials

Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules

Start date: August 13, 2015
Phase: N/A
Study type: Interventional

It has been shown that insulin might be involved in the pathogenesis of thyroid growth. Objective To evaluate the impact of IR and metformin use on the volume of benign thyroid nodules (TNs). Methods A randomized clinical trial to placebo (P) or MTF use. Previous fine needle aspiration confirming the diagnosis is necessary to inclusion. Patients will receive similar tablets of MTF and placebo and instruct to take 3 tablets/day of MTF (500mg/tablet). Thyroid volume, as TN volume, will be assess by ultrasound, both in the beginning, six months and one year after randomization, by the same researcher blinded regarding location group. Blood samples to measure: TSH, FT4, TPO-Ab, lipid profile, glucose and insulin were done after 8h fasting.

NCT ID: NCT03174925 Completed - Clinical trials for Thyroid Gland Nodule

Ultrasound Elastography in Imaging Patients With Thyroid Nodules

Start date: January 24, 2014
Phase: N/A
Study type: Interventional

This clinical trial studies how well ultrasound elastography works in assessing the cancer status of potentially malignant thyroid nodules.

NCT ID: NCT03160482 Completed - Thyroid Nodule Clinical Trials

PACE4 in Thyroid Cancer

Start date: May 15, 2017
Phase:
Study type: Observational

The investigation of thyroid nodules is limited by the fact that up to 49% of the fine needle aspirations (FNA) performed are of "indeterminate cytological signification". Moreover, no fully reliable molecular marker for thyroid cancer have been described. The goal of this project is to study the expression of a specific kind of protein convertase in benign and in malignant thyroid nodules to determine its potential as a biomarker.